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阿托伐他汀对不稳定型心绞痛患者高敏C反应蛋白和基质金属蛋白酶-9的影响 被引量:15

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摘要 目的研究应用阿托伐他汀对不稳定型心绞痛(UA)患者血清高敏C反应蛋白(hsCRP)和基质金属蛋白酶(MMP)-9的影响。方法将106例UA患者随机分为2组,治疗组50例,对照组56例。对照组仅给予常规治疗,治疗组在常规治疗基础上加服阿托伐他汀40mg/d,共30d,分别检测2组患者治疗前后的血清hsCRP和MMP-9水平。结果治疗组与对照组治疗前TC、TG、LDL-C和HDL-C差异无统计学意义。治疗组治疗后TC、LDL-C水平明显降低,HDL-C水平明显上升,差异有统计学意义(P<0.01)。治疗组与对照组治疗前hsCRP和MMP-9差异无统计学意义。治疗组治疗后hsCRP和MMP-9水平较治疗前明显降低,差异有统计学意义(均P<0.01)。结论阿托伐他汀除调脂作用外,还有抗炎、稳定斑块及防止斑块破裂的作用。
作者 魏嵩昀
出处 《天津医药》 CAS 北大核心 2013年第1期59-60,共2页 Tianjin Medical Journal
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