摘要
目的探讨影响Ⅲ期上皮性卵巢癌复发的相关因素。方法选取Ⅲ期上皮性卵巢癌85例,其中复发组31例,未复发组54例。测定并比较2组患者的纤维蛋白原(FIB)含量、部分凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血酶原时间(APTT)、血小板计数(PLT)、血清癌抗原125(CA125)、术中腹水量、腹水肿瘤细胞学性质、FIGO分期、组织学类型及组织学分级、残留灶大小、术中盆腔或(和)腹主动脉淋巴结是否切除及术后2个月CA125下降情况。Logistic回归分析影响复发的相关因素。结果复发组术前PT、TT缩短,腹水肿瘤细胞学阳性率、≥2cm残留癌灶所占比例、未行淋巴结切除术及术后2个月CA125未降至正常所占比例与未复发组比较差异有统计学意义(P<0.05或P<0.01),多因素Logistic回归分析显示残留肿瘤≥2cm、腹水肿瘤细胞学阳性、术中未行淋巴结切除及术后2个月CA125未正常是复发的独立危险因素。结论残留灶大小、腹水肿瘤细胞学性质、淋巴结是否切除及术后2个月血清CA125水平可以作为预测Ⅲ期卵巢上皮性癌复发的重要参考因素。
Objective To discuss possible causes of stageⅢ recurrent ovarian epithelial cancer. Methods A total of 85 ovarian epithelial cancer patients （stage Ⅲ） were allocated to recurrent group （n=31） and non-recurrent group （n=54）. The levels of plasma fibrinogen （FIB）, plasma prothrombin time （PT）, thrombin time （TT） and activated partial thromboplastin time （APTI） were detected by automatic coagulation analyzer in patients with ovarian epithelial cancer. The blood platelet （PLT） was measured by Sysmex KX-21. The electrochemiluminescence method was used to measure the serum cancer antigen 125 （CA125）. The amount of ascites, cytology of ascites tumors, FIGO substages, histological type and grade, size of residual tumor during operation, pelvic or abdominal lymph node resectable or not, and CA125 level 2 months after operation were analyzed. The related factors of recurrence were analyzed. Results Results of univariate analysis showed that levels of PT and Tr were significantly shorter before operation in recurrent group. There were significant differences in the positive rate of ascites cytology, the rate of ≥2 cm residual tumor, the rate of unresected lymph node and the abnormal rate of CA125 2 months after operation between patients with recurrence and patients without recurrence （P 〈 0.05 or P 〈 0.01）. Results of multivariate analysis showed that ≥2 cm residual tumor,the positive rate of ascites cytology, the rate of unresected lymph node and abnormal rate of CA125 2 months after operation were important risk factors for recurrence in patients with ovarian epithelial cancer. Conclusion In patients with ovarian epithelial cancer of stagelll ,residual tumor, cytology of ascites tumors, lymph node resected or not and CA125 level 2 months after operation were important prognostic factors of recurrence.
出处
《天津医药》
CAS
北大核心
2013年第1期41-43,共3页
Tianjin Medical Journal
