摘要
目的:研究雌、孕激素受体(ER、PR)、C-erbB-2在子宫内膜癌(EC)中的表达及C-erbB-2与ER、PR表达的相关性,并探讨其临床意义。方法:采用免疫组化法检测70例EC组织中ER、PR、C-erbB-2的表达。结果:ER在EC中的表达率为58.6%,与组织学类型、临床分期及肌层浸润深度密切相关;PR在EC中的表达率为70%,与组织学类型、组织学分级、临床分期及肌层浸润深度密切相关;C-erbB-2在EC中的表达率为24.3%,与临床分期及肌层浸润深度密切相关,并且与ER、PR的表达相关。结论:ER、PR、C-erbB-2的表达与EC的发生、发展及预后密切相关。
Objective：To explore the expression of estrogen receptor （ER）, progesterone receptor （PR） and C - erbB - 2 in endometrial carcinoma （EC） and their relationship. Methods： Immunohistocbemical analyses of ER, PR and C -erbB -2 were performed in 70 EC cases. Results： The positive expression rate of ER was 58.6% and there was significant relation between ER and pathological type, clinical staging and myometrium invasion. The positive ex- pression rate of PR was 70% and there was significant relation between PR and pathological type, histological grades, clinical staging and myometrium invasion. The positive expression rate of C - erbB - 2 was 24.3% and there was sig- nificant relation between C -erbB -2 and clinical staging and myometrium invasion; There was also significant rela- tion between the expressions of C - erbB - 2 and ER, PR. Conclusion： The expressions of ER, PR and C - erbB - 2 are related to the occurrence development and prognosis of endometrial carcinoma.
出处
《现代肿瘤医学》
CAS
2013年第1期141-144,共4页
Journal of Modern Oncology
