摘要
目的:研究慢性肾功能不全(CRF)患者颈动脉波强(WI)值与其血清生化指标的相关性及其密切程度。方法:对47例确诊为CRF且未进行过血液透析治疗的患者进行颈动脉WI检查,常规测量收集该组患者各项血清生化指标:血肌酐(SCr)、尿素氮(BUN)、尿酸(UA)、胱抑素C(Cys C)、β_2-微球蛋白(β_2-MG)、视黄醇结合蛋白(RBP),对WI检查结果及其各项血清生化指标进行统计分析和相关性比较。32名无心血管疾患且常规体检及血生化检查均无异常的健康志愿者的颈动脉WI值作为对照。结果:CRF患者WI参数中瞬时加速波强(W1),瞬时减速波强(W2)、负向波面积(NA)、硬化参数(β)、应变弹性模量(Ep)、脉搏波传导速度(PWVβ)及管径增大指数(AI)均显著高于对照组,差异有统计学意义(P<0.05);CRF患者W1、W2、NA、β、Ep、PWVβ与其SCr、BUN、UA、Cys C、β_2-MG、RBP均分别呈不同程度的正相关,相关系数有统计学意义(P<0.05)。结论:测定CRF患者颈动脉WI值,与患者各项血清生化指标相结合,可以反映CRF患者心血管功能损害及其随肾功能改变的损害程度,有望在临床上对CRF患者心血管功能早期评估产生一定的指导意义。
Objective： To research the correlation between serum biochemical indicators of patients with chronic renal failure （CRF） and their carotid artery wave intensity （WI）. Methods： A total of 47 cases patients with CRF and without hemodialysis underwent WI examine, and their serum biochemical indicators were measured including serum creatinine （Scr, n=47）, blood urea nitrogen （BUN, n=47）, uric acid （UA, n=47）, cystatin C （n=39）, β2- microglobulin （β2-MG, n=39）, and retinol binding protein （RBP, n=35）. Another 32 healthy volunteers were set as control. Results： In CRF group, with instantaneous speed wave intensity （W1）, instantaneous reducing speed wave intensity （W2）, negative wave area （NA）, hardening parameters beta （β）, strain elastic modulus （Ep）, pulse wave transmission velocity （PWVβ）,and pipe diameter increase index （AI） were significantly higher than that respectively in normal group （all P〈0.05）; and these indices were separately positively correlated with Scr, BUN, UA, cystatin C, β2-MG, and RBP in chronic renal failure group （all P〈0.05）. Conclusion： Combination of the carotid artery WI value and the serum biochemical indicators can reflect their vascular damage and damage degree in CRF patients. WI detection could be expected to be a valuable indicator for early assessment cardiovascular function in CRF patients.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2013年第1期67-70,共4页
Medical Journal of Wuhan University
关键词
波强
慢性肾功能不全
血清生化指标
心血管功能
Wave Intensity
Chronic Renal Failure
Serum Biochemical Indicators
Vascular Function
