摘要
目的:观察人脐带间充质干细胞(UC-MSC)治疗脑梗死的临床效果和安全性。方法:脑梗死患者1 20例,随机分为2组:对照组、UC-MSC治疗组,每组60例。对照组采用常规药物治疗+康复训练;UC-MSC治疗组在对照组治疗的基础上,给予UC-MS治疗。采用FIM评分及FMA评分对2组患者治疗前及后神经功能进行评定,并对患者年龄、病程、治疗前FMA评分与治疗后症状改善程度进行相关性分析。结果:治疗后1周、1月、3月FIM评分及FMA评分与治疗前相比,对照组差异均无统计学意义(P>0.05).治疗组中治疗前与治疗后1周比较,FIM评分及FMA评分差异无统计学意义(P>0.05);治疗前与治疗后1月比较,FMA评分升高(P<0.05),FIM评分差异无统计学意义(P>0.05);治疗前与治疗后3月比较,FIM评分、FMA评分升高,差异均有统计学意义(P<0.05)。治疗后3月,对照组与治疗组比较.FlM评分、FMA评分升高,差异均有统计学意义(P<0.05)。治疗组中患者年龄、病程与治疗后改善程度呈负相关(P<0.05),FMA评分与治疗后改善程度无相关性(P>0.05)。治疗组中在治疗后有16例患者出现轻度不良反应(发生率为26.67%):主要是轻度发热,轻度头昏头痛,腰部酸痛。36例(随访率60%)患者随访超过了1年,未见与细胞治疗相关的不良反应发生。结论:US-MSC鞘内注射联合静脉滴注治疗脑梗死后运动功能障碍疗效明显,同时具有良好的安全性。
Objective： To observe the effects on clinical efficacy and safety of umbilical cord mesenchymal stem cells （UC-MSCs） for cerebral infarction. Methods： A total of 120 cases of cerebral infarction were randomly divided into two groups for conventional treatment （control group） and UC-MSCs treatment （UC-MSC group）, with 60 cases in each group. The FIM and FMA scoring were used to evaluate nerve function changes. The patients＇ age, disease course, FMA score before and after treatment were recorded and analyzed. Results： No changes in FIM and FMA scores were found in control group after treatment in three months. But FMA score increased signifieantly after UC-MSCs treatment for 1 month （P〈0.05）, and both FMA and FIM scores increased signifieantly after 3 months＇ treatment of UC-MSCs and higher than that respectively in control group （P〈0.05）. Age and course of disease, rather than FMA score, were related factors for the outcomes of UC-MSCs treatment （P〈0. 05）. Mild adverse reactions such as fever, dizziness or headache, and lower baek pain, were found in 16 eases after UC-MSCs treatment. There were 36 cases in UC-MSC group followed up for more than one year, and no serious adverse reaction occurred. Conclusion： US-MSC intrathecal injection combined with intravenous infusion shows curative effect with good safety in the treatment of motor dysfunction after cerebral infarction.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2013年第1期57-60,70,共5页
Medical Journal of Wuhan University
关键词
人脐带间充质干细胞
脑梗死
运动功能障碍
Umbilical Cord Mesenchymal Stem Cells
Cerebral Infarction
Motor Dysfunction
