摘要
目的分析药品不良反应的发生特点和规律,探讨促进临床合理用药的对策及措施,预防、减少药品不良反应发生。方法查阅收集近两年来15余篇文章中有关药品不良反应综合报告中的1041例,进行分类统计和分析。结果 1041例药品不良反应中,女性547例高于男性494例;老年人(>60岁)发生例数最多为331例,占31.8%;经静脉给药方式引发的药品不良反应为830例,占79.73%;抗感染药物和中药制剂引发的药品不良反应最多,分别占44.09%、21.04%;药品不良反应主要临床表现以皮肤及其附件损害最多为556例,占47.16%。结论药品不良反应监测中应加强对抗感染药物和中药制剂的监测,提高合理用药水平是减少发生的关键,针对药品不良反应的特点和规律实施防范和干预措施,保障患者用药安全。
Objective To investigate the characteristics of adverse drug reaction （ADR）,explore the countermeasures of promoting rational clinical use of drugs, prevent and reduce the occurrence of ADR. Methods 1 041 cases of ADR from more than 15 comprehensive ADR reports published Within the recent two years were collected,and classified statistics and anaiytieal methods were carried out. Results 547 out of 1 041 cases of ADR were detected in women,which exceeded 494 cases of that in men.Aged people （over 60-year old） had the majority of 331 cases.which accounted for 31.8%;830 Cases were caused by intravenous administration and these accounted for 79.73%;the most ADR cases were caused by improper use of anti-infectives and traditional Chinese medicine,these two accounted for 44.09% and 21.04% respectively;skin and appendages disorder was the major clinical manifestations of ADR,which were 556 of cases and accouted for 47. 16%. Conclusion Monitoring the usage of anti-infective drugs and traditional Chinese medicine should be strengthened in ADR monitoring;improving rational use of drugs is the key to reducing ADR;prevention and intervention measures should be implemented according to ADR characteristics so as to ensure patients＇ medication safety.
出处
《中国医药科学》
2013年第1期149-150,167,共3页
China Medicine And Pharmacy
关键词
药品不良反应
回顾性分析
对策
Adverse drug reaction
Retrospective analysis
Countermeasures
