摘要
目的探讨代谢综合征患者空腹血清胰岛素样生长因子-1和高敏C反应蛋白与MS的关系。方法观察组为笔者所在医院门诊2012年2月～2012年8月收治的45例MS患者,对他们身高、体重、腰围、臀围、血压、空腹血糖、血脂及相关资料进行收集,对体重指数、腰臀比进行计算,并对血清IGF-1和hs-CRP浓度进行测定,对照组则选取健康体检者27例。结果观察组与和照组相比,血清hs-CRP的浓度升高,差异有统计学意义(P<0.01)。而血清IGF-1浓度降低,差异有统计学意义(P<0.05)。血清IGF-1和hs-CRP水平呈负相关。在观察组中,IGF-1的影响因素可能是LDL-C、hs-CRP;在对照组中,只有hs-CRP可能是IGF-1的影响因素。结论观察组患者存在低度慢性炎症,低IGF-1浓度与高hs-CRP水平提示了代谢综合征的一些可能的病理生理机制。
Objective To investigate the relationship of metabolic syndrome, serum insulin-like growth factor -1 and high sensitive C reactive protein. Methods 45 patients with MS in the author＇s hospital from February 2012 to August 2012 were the observation group and 27 healthy examined persons were the control group. The height, weight, waistline, hipline, blood pressure, fasting blood glucose, blood lipids and related data of two groups were collected. The body mass index and waist hip ratio （WHR） were calculated, and the serum ]GF-1 and hs-CRP concentration were measured. Results The concentration of hs-CRP of the observation group was higher than that of the control group （P 〈 O.DI）, while the concentration of IGF-1 was lower （P 〈 0.05）,There was negative correlation between the serum IGF-1 and hs-CRP concentration. In observation group, the affecting factors of IGF-1 were probably LDL-C and hs- CRP, while in the control group, only hs-CRP was probably the influence factors of IGF-1. Conclusion The patients in the observation group have low-grade chronic inflammation. The low IGF-1 concentration and high Hs-CRP levels suggests that some possible pathophysiologieal mechanisms of MS.
出处
《中国医药科学》
2013年第1期77-78,84,共3页
China Medicine And Pharmacy
