摘要
良性淋巴上皮病变（BLEL）又称Mikulicz病，以双侧或单侧泪腺弥漫性无痛性肿大为主要的眼部临床表现。关于该病病因及发病机制有性激素假说、转化生长因子-β（TGF—β）参与假说、基底细胞浸润增生假说、IgG4相关性假说等；该病典型的病理改变为腺体的淋巴细胞增生浸润、腺体实质萎缩、肌上皮岛在腺导管内的增生浸润所引起的腺管扩张。目前有关该病的诊断尚无统一公认的标准，临床上主要应与Sjfigren综合征及炎性假瘤进行鉴别，应用糖皮质激素为其主要的治疗手段，效果不佳时则辅以泪腺区体外放射治疗和／或手术切除。
Benign lymphoepithelial lesion（BLEL） is known as Mikulicz disease. The clinical manifestation of BLEL mainly includes diffuse painless enlargement of the eye or the monocular lachrymal gland. The etiology and pathogencsis of the disease proposed mainly concerns the sex hormone hypothesis, transforming growth factor-β involvement hypothesis, basal cell hyperplasia invasion hypothesis, and IgG4-related hypothesis, etc.. The typical pathological changes are infiltration of lymphocytes in the gland, atrophy of the gland tissue, formation of myoepithelial islands within the duct hyperplasia in the gland caused by infiltration of the tubular expansion. There is no uniform diagnosis criterion for this disease up to now, but it needs to be differentiated from idiopathic orbital inflammatory pseudotumor and SjSgren syndrome in clinical diagnosis. The application of glueocorticoid is the primary treating regimen for benign lymphoepithelial lesion. Local radiation therapy and/or surgery extraction arc available to patients unsensitive to glucocorticoid therapy.
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2013年第1期96-100,共5页
Chinese Journal Of Experimental Ophthalmology
基金
国家自然科学基金项目（81170875）
北京市卫生系统高层次卫生技术人才培养计划项目（2011-3-041）
关键词
良性淋巴上皮病变
泪腺
病因
发病机制
病理学
诊断
鉴别诊断
治疗
预后
Benign lymphoepithelial lesion
Lacrimal gland
Etiology
Pathogenesis
Pathology
Diagnosis
Differential diagnosis
Treatment
Prognosis
