摘要
糖尿病视网膜病变（DR）是糖尿病严重的微血管并发症之一，也是导致糖尿病患者低视力和致盲率升高的主要原因之一，严重影响了糖尿病患者的生活质量。DR的发病机制目前尚不明确，近年来有文献报道，炎症反应以及C反应蛋白（CRP）、单核细胞趋化因子-1（MCP-1）及细胞间黏附分子-1（ICAM-1）、白细胞介素（IL）、肿瘤坏死因子-α（TNF—α）、血清淀粉样蛋白A（SAA）等炎性因子与该病变的发生发展密切相关，应用糖皮质激素、非甾体类抗炎药（NSAIDs）、盐酸米诺环素及炎性因子拮抗剂抑制炎症反应过程可为治疗DR开辟新的途径。就炎症反应和炎性因子在DR发病机制中作用的研究进展以及利用抑制炎症反应及炎性因子的方法治疗DR的机制进行综述。
Diabetic retinopathy （DR）, one of the most serious microvascular complications of diabetes mellitus,leads to the increasing blindness rate,which seriously affects the quality of life in diabetic patients. Although the actual mechanism of DR is not yet completely clear, mounting evidence suggests that the development of DR may be associated with inflammatory processes and inflammatory factors, such as C-reactive protein （CRP）, chemotatic factor, adhesion molecule, interleukin, tumor necrosis factor-α （TNF-α） , serum amyloid A （ SAA ）. Usage of glucocorticoids,non-steroidal anti-inflammatory drugs （NSAIDs） , minocycline and anti-inflammatory factors to inhibit inflammatory process would be a new approach to the treatment of DR. This article reviews the current studies about the effects of inflammatory reaction and inflammatory factor in the pathogenesis of DR, mechanism of suppressing inflammatory response and anti-inflammatory factor in the treatment of DR.
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2013年第1期86-90,共5页
Chinese Journal Of Experimental Ophthalmology
关键词
糖尿病视网膜病变
炎症反应
炎性因子
抗炎药物
Diabetic retinopathy
Inflammatory reaction
Inflammatory factor
Anti-inflammatory drug
