摘要
目的观测兔牙槽骨局部缺损后应用复方白芨胶/珍珠层粉的修复效果及复合材料降解吸收情况。方法 60只兔分3组,Ⅰ组:骨缺损处植入白芨胶/珍珠层粉复合材料;Ⅱ组:单纯珍珠层粉;Ⅲ组:不填充材料。分别在术后1、4、8、12周行影像学、骨密度、大体解剖学观察、组织学及碱性磷酸酶活性测定,评价骨缺损修复及材料降解情况。结果珍珠层粉与白芨胶粉生物相容性均良好,术后12周时各组材料均降解完成。Ⅰ组骨缺损修复最快。12周时Ⅰ组骨密度值为(0.41±0.02)g.cm-2,大于Ⅱ组,Ⅱ组大于Ⅲ组。术后各时间点碱性磷酸酶活性Ⅰ组最高。结论中药复方白芨胶/珍珠层粉能较快地修复局部牙槽骨缺损,为临床中药治疗牙槽骨缺损开辟了新方向。
Objective To observe the repair effect and the degradation and absorption of the bletilla glucomannan/nacre powder composites in application of the rabbit alveolar bone＇ s local defect. Methods 60 rabbits were divided into 3 groups. Group Ⅰ ： defect was filled with bletilla glucomannan / nacre powder composites; GroupⅡ ： defect was filled with nacre powder; Group Ⅲ ： defect was not filled with any implants. The effects were observed by imaging, bone mineral density（BMD）, gross anatomy, histological, and alkaline phosphatase（ALP） at 1,4,8,12 weeks after surger- y. Results The nacre powder and bletilla glucomannan had a good biocompatibility. Implant material of the three groups had an entirely degradation at 12 weeks after surgery. Group Ⅰhad a better osteogenesis ability than groupⅡ and Ⅲ. The B MD （0.411 ± 0. 0188 ）g .cm-2 of group Ⅰ was greater than that of groupⅡ and the B MD of groupⅡwas greater than that of groupⅢ at 12 weeks after surgery（P 〈 0.05）. At the same postoperative time points, the ALP activity of the group Ⅰ was significantly greater than that of group Ⅱ and Ⅲ. Conclusion Chinese medicine bletilla glucomannan/pearl powder composites can repair partial alveolar bone defect quickly, and open up a new direction for Chinese medicine treatment of alveolar bone defect.
出处
《山东大学学报（医学版）》
CAS
北大核心
2013年第1期37-41,45,共6页
Journal of Shandong University:Health Sciences
基金
山东省自然科学基金(ZR2010HL014)
关键词
牙槽骨缺损
移植材料
生物相容性材料
白芨胶
纳米珍珠层粉
Alveolar bone defect
Graft material
Biocompatible material
Bletilla glucomannan
Nano-pearl powder
