摘要
利用形成碳-氧键将磷铵两性离子(1)共价键合到聚苯乙烯(PS)材料表面,改善其抗凝血性能.首先对PS进行氯甲基化反应,生成苄氯结构,然后通过自合成化合物1中的—OH与氯甲基化聚苯乙烯的—CH2Cl反应形成醚键,将两性离子接枝在PS上.表征了产物结构,并通过水接触角和血小板黏附实验对结构修饰前后材料的亲水性和抗凝血性能进行了比较.结果表明,磷铵两性离子结构修饰的聚苯乙烯材料可以有效地提高其血液相容性.
To be more compatible with blood, polystyrene （PS） was covalenfly-attached with phosphorylcho-line （1） via ether bond. After activated by chloromethylation reaction, the PS was constructed with compound 1 by the reaction between benzyl chloride and hydroxyl group. The existence of phosphorylchohne structure onto the surface of PS was revealed by attenuated total reflection Fourier transform infrared spectroscopy （ ATR- FTIR） and 1H NMR. The contact angle measurement of grafted PS membrane indicated that the grafted films possessed relatively hydrophilic surface. The blood compatibilities of grafted PS were evaluated by platelet-rich plasma adhesion experiment. The novel segmented PS containing phosphorylcholine structure improved blood compatibility.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2013年第1期205-209,共5页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:20874047)
江苏省高校优势学科建设工程资助项目资助
关键词
聚苯乙烯
磷铵两性离子
表面改性
血小板黏附
抗凝血生物材料
Polystyrene
Phosphorylcholine zwitterion
Surface modification
Platelet adhesion
Antithrombo- genic biomaterial
