摘要
目的探测6-异前列腺素F1α(6-k-PGF1α)在子宫颈癌患者血清中的表达,并初步探讨其与子宫颈癌发生发展的关系。方法采用ELISA法检测2010年6月至2012年6月在我院妇科确诊为子宫颈癌的(25例)患者血清中6-k-PGF1α的表达水平和正常宫颈(15例)及癌前病变(44例)组织中的表达水平的差异,分析并探讨6-k-PGF1α与子宫颈癌的关系,其中CINⅠ患者12例,CINⅡ患者14例,CINⅢ患者18例。结果①子宫颈癌前病变组(CIN)以及子宫颈癌组血清中6-k-PGF1α的表达明显高于正常子宫颈组(P<0.05);②子宫颈癌组血清中6-k-PGF1α的表达明显高于子宫颈癌前病变组(CIN)(P<0.05);③CINⅢ组血清中6-k-PGF1α的表达明显高于CINI或CINⅡ组(P<0.05),而CINⅠ与CINⅡ组患者之间血清6-k-PGF1α的表达没有统计学差异(P>0.05)。结论子宫颈癌前病变(CIN)患者以及子宫颈癌患者血清中6-k-PGF1α的表达明显升高,其与子宫颈癌的发生及恶性程度存在着一定的相关性。血清中6-k-PGF1α的表达水平对于提示子宫颈的恶性病变具有重要的意义,可作为子宫颈癌的辅助诊断及恶性程度的参考指标之一。
Objective To investigate the expression of 6-k-PGF1α in serum of cervical cancer and explore the relationship between 6-k-PGF1α in serum and the tumor development. Methods Expression of 6-k-PGF1α was detected by ELISA assay kit. 84 patients from June 2010 to June 2012 were selected and divided into different groups： control group （n = 15）, cervical cancer group （n = 25）, CIN group （n = 44） including 12 CIN I patients, 14 CIN II patients, and 18 CIN III patients. Results （1）Expression of 6-k-PGF1α in groups of CIN and cervical cancer was significantly higher than that in control group; （2）6-k-PGF1α expressed in cervical cancer group was significantly higher than that in CIN group; （3）Expression of 6-k-PGF1α in CINIII was much higher than that in CIN I or II group, however, there was no significant difference between CIN I and II. Conclusions 6-k-PGF1α expression increasing obviously in CIN and cervical cancer patients is related with cervical cancer decelpoment, which suggests an important significance of malignant lesions of the cervix, as well as one of the reference indices in the auxiliary diagnosis and malignant degrees of the cervical cancer.
出处
《临床医学工程》
2013年第1期35-36,共2页
Clinical Medicine & Engineering
