摘要
目的观察清热凉血解毒法对五步蛇咬伤患者凝血功能的影响。方法五步蛇咬伤患者69例随机分为对照组36例、治疗组33例。对照组采用常规治疗方案,治疗组在此基础上加用犀角地黄汤和五味消毒饮。观察2组患者入院后12、24、36、48h的血小板(PLT)、凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和纤维蛋白原(FIB)变化情况。结果入院后12h时比较PLT、TT、PT、APTT以及FIB皆未见有显著性差异。但至24h时,治疗组的PLT、TT、APTT与对照组比较有统计学意义(P<0.05)。36h时2组的TT和APTT比较有统计学意义(P<0.05)。48h时2组患者的凝血功能都基本恢复了正常水平。治疗组PLT从12h到24h时点上升趋势较对照组明显,但2组患者FIB的变化趋势相近。治疗组24h以及36h时点TT和APTT较对照组下降趋势更为明显。2组患者PT的变化趋势并未表现出显著的差异。结论清热凉血解毒法有助于促进五步蛇咬伤患者凝血功能的恢复。
OBJECTIVE To observe influence of clearing heat, cooling blood and relieving toxin method on blood coagula- tion of patients bitten by long-noded pit viper. METHODS There were totally 69 cases of patients bitten by long-noded pit vi- per in Guilin Hospital of Traditional Chinese Medicine from May 2008 to May 2012, who were randomly divided into control group （36 cases） and treatment group （33 cases）. The control group used the conventional treatment, while the treatment group added Xijiao Dihuang Decoction and Wuwei Xiaodu Decoction. Platelet （PLT）, thrombin time （TT） and prothrombin time （PT）, activated part clotting live enzyme time （APTT） and fibrinogen （FIB） of patients in two groups were observed 12, 24, 36 and 48 hours after administration. RESULTS PLT, TT, PT, APTT and FIB were not significantly different 12 hours after administration. But after 24 hours, PLT, TT and APTT in treatment group were statistically significant compared with control group （P^0.05）. TT and APTT of two groups at 36th hour were statistically significant （P%0.05）. Blood coagula- tion functions in two groups at ~Sth hour were basically returned to normal level. The rising trend of PLT in treatment group from 12h to 24h was more obvious compared with control group, while the change tendency of FIB in two groups was similar. TT and APTT in treatment group from 24th to 36th hour declined more apparently than control group. The change trend of PT in two groups did not show significant difference. CONCLUSION Clearing heat, cooling blood and relieving toxin method promotes the blood coagulation function recovery of patients bitten by long-noded pit viper.
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2013年第1期12-15,共4页
Journal of Nanjing University of Traditional Chinese Medicine
基金
广西壮族自治区科技厅科技攻关项目(桂科攻1140003B-92)
关键词
清热凉血解毒
犀角地黄汤
五味消毒饮
五步蛇
凝血功能
clearing heat, cooling blood and relieving toxin
Xijiao Dihuang Decoction
Wuwei Xiaodu Decoction
Long-no- ded pit viper
blood coagulation function
