摘要
目的探讨硫酸镁治疗重型颅脑创伤的疗效。方法选择鹿寨县人民医院神经外科2008年6月至2011年6月收治的重型脑创伤患者86例,随机分为对照组(29例)、MgSO4组(28例)和MgSO4+利多卡因组(29例)。对照组仅给予常规疗法,MgSO4组在常规治疗基础上给予MgSO4治疗,MgSO4+利多卡因组在常规治疗基础上给予MgSO4及利多卡因治疗,比较三组的相关指标并进行评价。结果对照组、MgSO4组、MgSO4+利多卡因组治疗第3天时血Mg2+浓度分别为(0.79±0.26)、(0.85±0.27)、(0.81±0.30)mmol/L,三组间比较差异无统计学意义(P>0.05),MgSO4组Mg2+浓度较入院时明显升高且差异有统计学意义(P<0.05);对照组、MgSO4组、MgSO4+利多卡因组治疗1周时血神经元烯醇化酶(NSE)浓度分别为(20.9±18.5)、(11.3±10.6)、(11.5±11.0)μg/L,对照组与MgSO4组、MgSO4+利多卡因组分别比较,差异均有统计学意义(P<0.05),而MgSO4组与MgSO4+利多卡因组比较差异无统计学意义(P>0.05);对照组、MgSO4组、MgSO4+利多卡因组治疗6个月后疗效评价较好者所占比例分别为27.6%、39.3%、51.7%,组间比较差异无统计学意义(P>0.05)。结论早期补充MgSO4治疗重型颅脑创伤能明显提高患者血清Mg2+、NSE浓度,改善患者预后起积极作用。
Objective To investigate the effect of magnesium sulfate in the treatment of severe craniocerebral trauma.Methods Eighty-six patients with severe cerebral trauma who were treated in our department between June 2008 and June 2011 were selected.They were randomly divided into control group（29 cases）,MgSO4 group（28 cases）,MgSO4 and lidocaine group（29 cases）.Patients in control group were only received conventional therapy.Patients in MgSO4 group were treated with MgSO4 on the basis of conventional therapy,and patients in MgSO4 and lidocaine group were treated with MgSO4 and lidocaine on the basis of conventional therapy.The relateod indicatrs of the three groups were compared and evaluated.Results At the third day,the serum of Mg2＋ concentration of control group,MgSO4 group,MgSO4 and lidocaine group was（0.79±0.26）,（0.85±0.27） and（0.81±0.30）mmol/L,respectively.The difference among the three groups had no statistical significance（P0.05）.The serum of Mg2＋ concentration of MgSO4 group were significantly elevated than on admission,the difference was statisticcally significant（P0.05）.At the seventh day,the serum of NSE concentration of control group,MgSO4 group,MgSO4 and lidocaine group was（20.9±18.5）,（11.3±10.6）,（11.5±11.0）μg/L respectively.There was significant difference that control group was respectively compared with MgSO4 group,MgSO4 and lidocaine group（P0.05）.There was no significant difference between MgSO4 group and MgSO4 and lidocaine group（P0.05）.After six months,patients has better effect in control group,MgSO4 group,MgSO4 and lidocaine group accounted for 27.6%,39.3%,51.7%,respectively.The differences among the three groups had no statistical significance（P0.05）.Conclusion Early supplement of MgSO4 in the treatment of severe craniocerebral trauma patients can significantly improve the serum of Mg2＋ and NSE concentration,and play a positive role in improving prognosis of patients.
出处
《临床医学》
CAS
2012年第12期8-10,共3页
Clinical Medicine
关键词
重型颅脑创伤
硫酸镁
格拉斯哥评分
Severe craniocerebral trauma
Magnesium sulfate
GOS score
