氨溴索注射液辅治慢性支气管炎疗效观察被引量：4

导出

摘要目的观察氨溴索注射液辅治慢性支气管炎的效果。方法将60例慢性支气管炎患者随机分为治疗组和对照组各30例。对照组给予抗炎、止咳、对症等治疗;治疗组在对照组治疗基础上加用氨溴索注射液治疗。治疗后观察2组临床疗效、血气分析及不良反应。结果治疗组总有效率为93.3%高于对照组的76.7%,差异有统计学意义(P<0.05)。治疗组治疗后PaO2和PaCO2水平均优于对照组,差异均有统计学意义(P<0.05)。2组均未发生严重不良反应。结论氨溴索注射液辅治慢性支气管炎临床疗效确切,不良反应小,值得临床推广应用。

作者李剑

机构地区内蒙古自治区阿拉善盟阿左旗妇幼保健院

出处《临床合理用药杂志》 2013年第1期70-70,共1页 Chinese Journal of Clinical Rational Drug Use

关键词氨溴索注射液支气管炎慢性

分类号 R562.21 [医药卫生—呼吸系统]

引文网络
相关文献

参考文献3

1朱科明,邓小明.沐舒坦对呼吸系统的保护作用及机制[J].上海医学,2000,23(10):637-639. 被引量：336
2李海东,刘国祥.沐舒坦药理作用机制[J].中华医学丛刊,2004,4(10):34-36. 被引量：52
3舒思静.沐舒坦治疗毛细支气管炎的临床观察[J].医学理论与实践,2002,15(8):922-923. 被引量：11

二级参考文献14

1吴瑞萍胡亚美.实用儿科学（第6版）[M].北京:人民卫生出版社,1996.676.
2[1]Gillissen A, Nowak D. Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy. Respir Med, 1998, 92:609-623.
3[2]Teramoto S, Suzuki M, Ohga E, et al. Effects of ambroxol on spontaneous or stimulated generation of reactive oxygen species by bronchoalveolar lavage cells harvested from patients with or with-out chronic obstructive pulmonary diseases. Pharmacology,1999, 59:135-141.
4[3]Gillissen A, Bartling A, Schoen S, et al. Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung, 1997, 175:235-242.
5[4]Park NH, Han ES, Lee CS, et al. The inhibitory effect of ambroxol on respiratory burst, de granulation and cytosolic Ca2+ change in degraded immunoglobulin G-activated neutrophils. Pharmacol Toxicol, 1999, 84: 81-87.
6[5]Pfeifer S, Zissel G, Kienast K, et al. Reduction of cytokine release of blood and bronchoalveolar mononuclear cells by ambroxol. EurJ Med Res, 1997, 2:129-132.
7[6]Stettner S, Ledwozyw A. The effect of Ambroxol on bleomycininduced changes in phospholipid composition of rat lung surfactant. Acta Physiol Hung, 1995, 83:181-187.
8[7]Mira E, Benazzo M, De Paoli F, et al. Surfactants of the air-ways. Critical review and personal research. Acta Otorhinolaryngol Ital, 1997, 17(1 Suppl 56):3-16.
9[8]Nemcekova E, Nosalova G, Franova S. Ambroxol and protective reflexes of the respiratory tract. Bratisl Lek Listy, 1998, 99:111-115.
10[9]Tyrakowski T, Greczko Ⅰ, Sedlaczek A, et al. Electrophysiological investigation of the effects of ambroxol on the transepithelial Na + ion transport pathway in airways. Pol J Pharmacol,1998, 50:31-38.