摘要
[目的]探讨限蛋白质饮食联合复方α-酮酸治疗对2型糖尿病肾病（DN）患者营养状况、肾功能、血糖的影响，并进一步探讨蛋白质最佳摄入量及复方α-酮酸的最佳补充量。[方法]选择2型DN肾病患者45例，随机分为三组，分别予以单独低蛋白饮食（C组）、低蛋白饮食联合复方α-酮酸（A组）和极低蛋白饮食联合复方α-酮酸（B组）治疗40周，比较各组治疗前及治疗后所测定的营养状况、肾功能和代谢的相关指标。[结果]A、B组的血清尿素氮治疗后较治疗前有降低（P〈0．05），且治疗后A、B组血清尿素氮降低程度与C组比较差异有统计学意义（P〈0．05）。A、B组的血清白蛋白和前白蛋白治疗后较治疗前有升高，治疗后A、B组血清白蛋白和前白蛋白升高程度与C组相比差异有统计学意义（P〈0．05），而治疗后A组血清白蛋白和前白蛋白较B组上升得更多（P〈0．05）。[结论]低蛋白或极低蛋白饮食联合复方α-酮酸治疗可以改善单纯低蛋白饮食所致的营养不良，而低蛋白饮食联合复方α-酮酸可以更好地保持糖尿病肾病患者的营养状态。
[Objective]To explore the effect of protein-restricted diet combined with α-kerose compound on nutritional status, renal function and blood glucose of patients with type 2 diabetic nephropathy（DN）, and to further explore the optimal dietary protein intake and α-ketose supplement. [Methods]Forty-five DN patients were divided into three groups given low-protein diet（LPD）, low-protein diet combined with α-ketose（group A） and very-low-protein diet（VLPD） combined with a-ketose（group B） respectively for 40 weeks. The nutritional status, renal and metabolic indicators were determined before and after treatment. [Results] Compared with before treatment, serum urea nitrogen in group A and B decreased after treatment（ P 〈0.05）. Compared with control group, serum urea nitrogen in group A and B after treatment decreased, and there was significant difference（ P 〈0.05）. Compared with before treatment, serum albumin and prealbumin in group A and B increased after treatment. Compared with control group, serum albumin and prealbumin in group A and B increased after treatment（ P d0.05）, but serum albumin and prealbumin in group A increased more obviously than those in group B（ P 〈0.05）. [Conclusion]LPD or VLPD combined with α-ketose compound can improve malnutrition caused by LPD. LPD combined with α-ketose compound can preferably preserve the nutritional status of DN patients.
出处
《医学临床研究》
CAS
2012年第12期2313-2315,共3页
Journal of Clinical Research
