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正五聚蛋白3在脓毒症患者中的变化及意义 被引量：3

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摘要 目的探讨炎性指标正五聚蛋白3（PTX3）在脓毒症患者中的变化及与脓毒症的关系。方法选择入住ICU在24h以上的脓毒症患者70例为观察组，同期体检健康者15例为对照组，采用酶联免疫吸附测定法（ELISA）检测血浆PTX3水平。结果观察组的血浆PTX3为（28．1±9．6）ng／ml高于对照组血浆PTX3（11．4±4．3）ng／ml，差异有统计学意义（P〈0．05）；严重脓毒症组的血浆PTX3水平为（39．0±10．8）ng／ml高于脓毒症组血浆PTX3（18．98±7．16）ng／ml，差异有统计学意义（P〈0．05）。结论PTX3和脓毒症的严重程度密切相关，可作为脓毒症的一个新的炎性指标。
作者 李菲菲 孙荣青 张少雷 杨宏富 马宁
机构地区 郑州大学第一附属医院ICU 河南中医学院第一附属医院ICU
出处 《中国实用医刊》 2013年第2期94-95,共2页 Chinese Journal of Practical Medicine
关键词 正五聚蛋白3 脓毒症 炎症
分类号 R459.7 [医药卫生—急诊医学]
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参考文献9

  • 1Pappachan JV,Conlson TG,Child N J. Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF-238a polymorphism[J].Immunogenetics,2009,(10):657-662.
  • 2Penack O,Buchheidt D,Christopeit M. Management of sepsis in neutropenic patients:guidelines from the infectious diseases working party of the German Society of Hematology and Oncology[J].Annals of Oncology,2011,(05):1019-1029.
  • 3Botazzi B,Bastone A,Doni A. The long pent raxin PTX3 as a link among innate immunity,inflammation,and female fertility[J].Journal of Leukocyte Biology,2006,(05):909-912.
  • 4Bottazzi B,Garlanda C,Salvatori G. Pentraxins as a key component of innate immunity[J].Current Opinion in Immunology,2006,(01):10-15.doi:10.1016/j.coi.2005.11.009.
  • 5Latini R,Maggioni AP,Peri G. Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction[J].Circulation,2004,(16):2349-2354.
  • 6Von Eyben FE,Mouritsen EA,Holm J. Fibrinogen and other coronary risk factors[J].Metabolism-Clinical and Experimental,2005,(02):165-170.
  • 7潘景业,王晓东,张艳杰,金可可,王明山.炎症与血栓形成[J].中国预防医学杂志,2005,6(3):277-280. 被引量：19
  • 8Gustin C,Delalve E,Dieu M. Upregulate of pentaxin 3 in human endothelial cells after lysophosphatidic acid exposure[J].Arteriosclerosis,Thrombosis,and Vascular Biology,2008,(03):491-497.
  • 9Muller B,Peri G,Doni A. Circulating levels of the long pentraxin 3 PTX3 correlate with severity of infection in critically ill patients[J].Critical Care Medicine,2001,(07):1404-1407.

二级参考文献7

共引文献18

同被引文献42

  • 1Dombrovskiy VY, Martin AA, Sunderram J,et al. Rapid increasein hospitalization and mortality rates for severe sepsis in the UnitedStates : a trend analysis from 1993 to 2003 [ J ]. Crit Care Med,2007,35(5): 1244-1250.
  • 2Phillips CR, Chesnutt MS, Smith SM. Extravascular lung water insepsis-associated acute respiratory distress syndrome : indexingwith predicted body weight improves correlation with severity ofillness and survival [ J ]. Crit Care Med,2008,36 (1): 69-73.
  • 3Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsiscampaign : international guidelines for management of severesepsis and septic shock : 2012 [ J ]. Crit Care Med,2013,41 (2):580-637.
  • 4Garlanda C, Hirsch E,Bozza S, et al. Non-redundant role of thelong pentraxin PTX3 in anti-fungal innate immune response [ J ].Nature,2002,420 (6912) : 182-186.
  • 5Riedel S, Carroll KC. Laboratory detection of sepsis : biomarkersand molecular approaches [ J ]. Clin Lab Med,2013,33 (3):413-437.
  • 6Napoleone E, Di Santo A, Bastone A, et al. Long pentraxin PTX3upregulates tissue factor expression in human endothelial cells :a novel link between vascular inflammation and clotting activation[J]. ArteriosclerThromb Vase Biol, 2002,22 (5): 782-787.
  • 7Mauri T, Coppadoro A,Bellani G, et al. Pentraxin 3 in acuterespiratory distress syndrome : an early marker of severity [ J ].Crit Care Med,2008,36 (8): 2302-2308.
  • 8Mauri T,Bellani G, Patroniti N, et al. Persisting high levels ofplasma pentraxin 3 over the first days after severe sepsis and septicshock onset are associated with mortality [ J ]. Intensive CareMed,2010,36 (4) : 621-629.
  • 9Muller B,Peri G, Doni A, et al. Circulating levels of the longpentraxin PTX3 correlate with severity of infection in critically illpatients [ J ]. Crit Care Med,2001,29 (7) : 1404-1407.
  • 10Sakka SG, Klein M, Reinhart K, et al. Prognostic value ofextravascular lung water in critically ill patients [ J ]. Chest,2002,122 (6) : 2080-2086.

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中国实用医刊
2013年 第2期

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