摘要
目的观察养阴清肺方治疗女性青春期后痤疮的临床疗效,探讨其可能的作用靶点。方法选择女性青春期后的Ⅱ级和Ⅲ级痤疮患者,随机分为治疗组33例,对照组30例,另选10例健康志愿者作为对照。治疗组口服养阴清肺方;对照组口服丹参酮胶囊。8周后对两组患者皮损和临床证候进行评估,并分别于治疗前后检测治疗组患者及健康志愿者血清双氢睾酮(DHT)、白介素-6(IL-6)、白介素-8(IL-8)。结果治疗组和对照组总有效率分别为96.97%和93.33%,差异无统计学意义(P>0.05);愈显率分别为84.85%和43.33%,治疗组优于对照组(P<0.05)。Ⅱ级痤疮患者治疗组与对照组的愈显率分别为85.00%和43.75%,治疗组优于对照组(P<0.05);Ⅲ级痤疮患者治疗组与对照组的愈显率分别为84.62%和42.86%,治疗组优于对照组(P<0.05)。两组治疗后中医证候积分均较治疗前降低(P<0.01),治疗组治疗后总积分、大便情况、心烦失眠积分改善情况优于对照组(P<0.05)。治疗前治疗组患者DHT、IL-6、IL-8水平均明显高于健康志愿者(P<0.05),治疗后上述3项指标均较治疗前下降(P<0.05),与健康志愿者比较差异无统计学意义(P>0.05)。结论中药养阴清肺方可有效治疗女性青春期后痤疮,改善临床证候,疗效机制可能与降低患者血清DHT、IL-6、IL-8水平有关。
Objective To observe the therapeutic effect of Yangyin Qingfei Decoction （yin-nourishing lung-clearing decoction） for female adult acne and its possible therapeutic targets. Methods Sixty-three cases of grade II to grade III female adult acne were randomized into the treatment group （33 cases） and control group （30 cases）. The treatment group was given Yangyin Qingfei Decoction orally and the control group was given Tanshinone Capsule orally. Ten healthy volunteers were chosen as controls. The skin lesions and TCM syndromes were observed after 8 weeks. The serum dihydrotestosterone （DHT）, interleukin-6 （IL-6） and IL-8 were detected before and after treatment. Results The total effective rate of the treatment group and control group was 96.97% and 93.33% respectively, with no significant difference between groups （P〉0.05）. The excellent rate of the treatment group and control group was 84.85% and 43.33% respectively, with a significant difference between groups （P〈0.05）. The excellent rate of grade II acne in the treatment group and control group was 85.00% and 43.75 % respectively, with a significant difference between groups （P〈0.05）. The excellent rate Of grade III acne in the treatment group and control group was 84.62% and 42.86% respectively, with a significant difference between groups （P〈0. 05）. The total scores and associated symptom scores in both groups were significantly decreased after treatment （P〈0.01）. The total score and scores of stool, upset and insomnia in the treatment group were significantly lower than those in the control group （P〈 0.01）. The levels of DHT, IL-6 and IL-8 in both groups were significantly higher than those of the healthy volunteers before treatment （P〈0.05）. The levels of DHT, IL-6 and IL-8 in both groups were significantly decreased after 8 weeks of treatment （P〈0.05）, with no significant difference comparing with the healthy volunteers （P〉0.05）. Conclusion Yangyin Qingfei Decoction is effective for female adult acne that may be relevant to reducing serum DHT, IL-6 and IL-8.
出处
《中医杂志》
CSCD
北大核心
2013年第2期134-137,共4页
Journal of Traditional Chinese Medicine
