摘要
目的:探索早期识别和降低老年人轻度认知功能障碍(MCI)患病率的途径。方法:随机选择调查宜春市399名60岁以上老年人,进行蒙特利尔认知评估(北京版)(MoCA)、哈金斯基缺血指数评分(HIS)、日常生活能力量表(ADL)等测查。并选取符合MCI诊断标准者和正常老年人各40例,抽取全血样本检测其ApoEε4等位基因进行对照研究。结果:共有符合MCI诊断标准者41名,患病率为10.28%。MCI患病率随增龄而增高,与受教育水平成反比,农村显著高于城市,体力劳动者显著高于脑力劳动者;在性别及婚姻状态上其差异无统计学意义。MCI组ApoEε4等位基因携带及频率分布与正常老年人组相比有显著差异(P<0.05)。结论:低教育水平、体力劳动者、生活在农村地区、高龄对MCI的患病有显著影响,ApoEε4基因携带可能是MCI患病的危险因素。对重点人群进行MoCA评估及ApoEε4基因测定,并进行相应干预,有助于减少和预防MCI的发生。
Objective： To explore the approach of early identification and reduced prevalence with mild cognitive impairment. Methods： A sample of 399 elder people aged 60 or above living in Yichun area were examined with Montreal cognitive assessment （MoCA）, Hachinski ischemia index score table （HIS） and active daily living assessment （ADL） . A control study was carried out between 40 patients with MIC and 40 healthy elderly subjects testing Apolipoprotein Ee4 allele （ApoEε4） . Result： Among the subjects visited, 41 （10. 28% ） were defined to have MIC. The prevalence rate of MIC was higher in people living in rural area, in people with lower educational attainment, and in people who were labor workers. The prevalence increased with age growing. There was no statistical significance in sex and marital status. ApoEε4 was significantly increased in MIC group vs normal group （ P 〈 0. 05） . Result： Advanced age, living in rural area, labor workers and lower educational attainmenthas remarkable effect on MIC. ApoEε4 might be the risk factors in MIC. Testing ApoEa-4 and examining MoCA on the key population is helpful to reduce and preventing MIC.
出处
《宜春学院学报》
2012年第12期77-79,共3页
Journal of Yichun University
基金
宜春市科技局社会发展类科技计划
项目编号:JXYC2010KSA012
