摘要
目的:找出能减小电荷积累和组织损伤的刺激波形。方法:先定义一个双极性矩形脉冲对大鼠的脊髓进行刺激,然后将该波形改为阶梯波形并在相同的位置进行刺激,比较在活体大鼠中阶梯波形和双极性矩形脉冲对刺激阈值的影响以及电荷量的关系。结果:在一阶阶梯刺激波形条件下,尽管刺激阈值V会随着负脉冲宽度T1的增加而增加,但一阶阶梯刺激波形的电荷总量都低于双极性矩形脉冲的电荷总量。增加阶梯数目i也会导致刺激阈值的增加,但阶梯数目1<i<4时其电荷总量低于双极性矩形脉冲的电荷总量。结论:使用低于四阶阶梯式双极性脉冲能减少因电荷的累积而对组织造成的损伤。
Objective：To find out a stimulus waveform that can reduce charge quantities and tissue damage. Methods：A bipolar rectangular pulse was defined and stimulated spinal cord of the rats, then staircase waveforms were used to stimulate the same location and compared the influences of the bipolar rectangular pulse and staircase waveform on the stimulus threshold values and charge quantities. Results：In the first step stimulus waveform, stimulus threshold value V would be increased when T1 increased, but the total charge amount was less than that of the bipolar rectangular pulse. Increasing step number i could also lead to the increase of the stimulus threshold value, however, the total charge amount is less only when 1i4. Conclusion：Using the staircase waveform with steps less than four can reduce tissue damage because of the accumulation of charge
出处
《现代电生理学杂志》
2012年第4期200-203,共4页
Journal of Modern Electrophysiology
基金
江苏省高校自然科学研究项目(11KJB510022)
东南大学生物电子学国家重点实验室开放研究基金(2011E05)
南通市科技计划项目(K2009037)
关键词
参考波形
阶梯波形
波形参量
电荷总量
reference waveform
staircase waveform
waveform parameter
charge amount
