摘要
目的 利用MRI对ChiariⅠ畸形病例进行颅脑形态学测量 ,探讨ChiariⅠ畸形的发病机制。方法 对不伴脑积水、不伴环枕融合的 18例ChiariⅠ畸形病例及 2 8例不伴中枢神经系统疾患者分别进行MRI颅腔、颅腔形态及颅脑测量 ,并对测量结果作统计分析。结果 ChiariⅠ畸形患者的后颅颅腔形态及后脑大小与对照组无显著性差异 (P >0 0 5 ) ,而后颅骨性结构及颅腔明显小于对照组 ,后颅脑颅比大于对照组 (P <0 0 1)。结论 MRI可以清楚显示颅腔内神经结构及重要骨性标志的准确位置。作者认为利用MRI进行形态学测量是可行的。ChiariⅠ畸形最可能的发病机制为胚胎枕节发育不良导致后颅狭小 ,难以完全容纳正常发育的后脑 ,使小脑扁桃体向下疝入椎管。ChiariⅠ畸形多见于成人或儿童晚期 ,可能是由于出生至 7岁前是颅骨生长迅速期 ,相对缓解了后颅拥挤状况。
Objective To study the morphological change of the skull and intracranial neural structures by MR and to determine the pathogenesis of Chiari Ⅰ malformation Methods Eighteen patients with Chiari Ⅰ malformation and 28 normal control subjects were studied using MRI In the Chiari Ⅰ malformation group, there was no hydrocephalus and occipitalization Results Compared to the control group, there was a significantly smaller posterior cranial fossa and a significantly larger posterior brain skull ratio in the Chiari Ⅰ group There was no significant differences in the posterior brain and morphology of posterior fossa between the two groups Conclusion In Chiari Ⅰ malformation, an underdeveloped occipital bone, possibly due to underdevelopment of occipital somite originating from the paraxial mesoderm, induces overcrowding in the posterior cranial fossa, bring the caudal part of the cerebellum downward herniation The skull develope faster than brain from born to 7 years, which may alleviate overcrowding in the posterior cranial fossa
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2000年第7期473-475,共3页
Chinese Journal of Radiology
关键词
ChiariⅠ畸形
磁共振成像
发病机理
Chiari Ⅰ malformation
Magnetic resonance imaging
Occipital bone
Cranial fossa,posterior
