摘要
目的 探讨晚期霍奇金病的合理治疗方法。方法 对 12 8例晚期霍奇金病的治疗结果进行了总结和分析。结果 总有效率 96 1% (12 2 / 12 7) ,其中完全缓解 (CR)率 6 8 5 %。化放疗组、单化疗组和单放疗组的CR率分别为 6 9 7%、5 8 3%和 10 0 %。全组 1,3,5 ,10年生存率分别为 91 4%、70 3%、5 6 8%和 5 2 4%。生存率分析显示 ,临床Ⅲ期、无全身症状、无巨块型、淋巴细胞为主型和结节硬化型、化放疗组 ,至少 6周期化疗 ,治疗后CR患者的 5 ,10年生存率优于临床Ⅳ期、有全身症状、巨块型、混合细胞型和淋巴细胞消减型、单放疗组 ,不足 6周期化疗的肿瘤部分缓解和无效患者 (P <0 0 5 )。结论 至少 6周期有效化疗 ,力争肿瘤完全缓解 。
Objective To explore the rational treatment for advanced Hodgkin′s disease.Methods A total of 128 patients with advanced Hodgkin′s disease was included in this study. They could be divided into 3 groups according to the treatment they received. Patients in group 1 ( n =99) were treated by combination chemotherapy plus radiotherapy. Patients in group 2 ( n =24) were treated by chemotherapy alone. The remaining 5 patients in group 3 were treated by radiotherapy alone. The chemotherapeutic regimens used were MOPP, MOPP alternating with CHOP, or with ABVD.Results The overall response rate of 127 evaluable patients was 96.1%. The overall 1 , 3 , 5, and 10 year survival rate was 91.4%, 70.3%, 56.8% and 52.4%, respectively. The complete response (CR) rate in the 3 groups of patients was 69.7%, 58.3% and 100%, respectively. Patients in clinical stage Ⅲ with no bulky mass, no systemic symptoms, and their tumor was predominantly of lymphocytic or nodular sclerotic type had better long term survival than those in clinical stage Ⅳ with bulky mass, systemic symptoms, and with lymphocyte depleting, mixed cellular tumor. Better long term survival was seen in patients who showed complete response to combined chemotherapy and radiotherapy. At least 6 cycles of chemotherapy were needed.Conclusion Combination chemotherapy plus radiotherapy is effective in the treatment of advanced Hodgkin′s disease.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2000年第4期333-335,共3页
Chinese Journal of Oncology
关键词
何杰金氏病
药物疗法
放射疗法
预后
Hodgkin′s disease/therapy
Hodgkin′s disease/drug therapy
Hodgkin′s diease/radiotherapy
Prognosis
