摘要
目的探讨LKB1蛋白在非小细胞肺癌中的表达情况及临床意义。方法应用免疫组化方法检测76例非小细胞肺癌中LKB1蛋白的表达情况。结果 LKB1蛋白在肺癌组织及癌旁正常肺组织中均有表达,LKB1在正常肺组织的阳性表达率显著高于癌组织(90.78%vs 65.79%,P<0.01)。LKB1蛋白在肺鳞癌和腺癌组织中的表达无显著性差异。LKB1蛋白在高分化肿瘤中的表达阳性率明显高于中-低分化肿瘤(81.82%vs53.49%,P<0.05)。LKB1蛋白在无淋巴结转移组的阳性表达率明显高于淋巴结转移阳性组(89.29%vs 52.08%,P<0.01)。结论 LKB1蛋白的低表达与肺癌的发生有关,并且影响肿瘤的分化及淋巴结转移,可能影响肺癌的预后。
Objective To investigate the expression of LKB1 protein and its clinical significance in non-small cell lung cancer （NSCLC）. Methods Immunohistochemical staining was performed to detect LKB1 protein in NSCLC tissue. Results The positive rate of the expression LKB1 protein in normal lung tissue was significantly higher than that of NSCLC tissue（90. 78% vs 65.79% ,P 〈 0. 01 ）. There was no difference in expression of LKB1 protein between squamous cell carcinoma and adenocarcinoma. The expression of LKB1 pro- tein in well-differentiated tumor was significandy higher than that of poorly differentiated tumors （81.82% vs 53.49%, P 〈 0. 05 ）. The ex-pression LKB1 protein in the negative lymph node group was significantly higher than that of the positive lymph node group （ 89. 29% vs 52. 08% , P 〈 0. 01 ）. Conclusions Low expression of LKB1 protein may be related to the occurrence of lung cancer, and the impact of tumor differentiation and lymph node metastasis, then affect the prognosis of lung cancer.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2013年第1期20-21,共2页
Chinese Journal of Gerontology
基金
河北省自然科学基金资助项目(No.C2009001262)
