摘要
目的 :研究大鼠脑发育不同时期学习记忆的变化及与NMDA受体通道动力学特性的关系。方法 :采用学习记忆行为和离子通道动力学特性测定相结合的方法。结果 :在爬杆主动回避反应中 ,发育早期大鼠习得和保持能力均明显强于成年大鼠。同时 ,发育早期大鼠训练后NMDA受体通道出现 5 0pS电导 ,而且 35 pS通道开放时间和开放概率增加 ,35 pS通道长开放成份增多 ,有长cluster开放。而成年大鼠 2 0pS、35 pS通道关闭时间常数明显长于年轻大鼠。结论 :大鼠学习记忆的发育变化与NMDA受体通道动力学特性有关。
Aim:To investigate the relationship between developmental changes of learning, memory and the kinetic properties of NMDA receptor channel. Methods:To use behaviour training and patch clamp technique. Results:Early developmental rats show the better ability in the acquisition and retention of pole jump active avoidance reaction(AAR) than that of adult rats. After AAR acquisition, 50 pS channel of NMDA receptor emerged in young rats, the open time, open probability, long cluster open components of 35 pS channel was also increased. But the close time constants of NMDA receptor channel of adult rats were longer than that of early deve lopmental rats. Conclusion: The ability of learning and memory was different between early development and adult rats, because of the different changes of the kinetic properties of NMDA receptor channel.
出处
《中国应用生理学杂志》
CSCD
2000年第1期18-21,共4页
Chinese Journal of Applied Physiology
