摘要
目的通过六分钟步行试验（6MWT），探讨抑郁对慢性阻塞性肺疾病（COPD）患者运动能力的影响。方法2009年9月至2011年4月，选择急性发作症状得到控制的COPD患者120例，根据汉密尔顿抑郁量表（HAMD）评分分组，其中HAMD评分〈7分者48例，为正常对照组；HAMD评分≥17分者60例，为抑郁组；7分≤HAMD评分〈17分为不确定患者是否抑郁，不纳入研究范围。入组患者进行6MWT，试验前后测定患者的血压、心率、呼吸频率、呼吸困难和疲劳评分（Borg指数）及血气分析，所有患者均测定BMI和肺功能。结果抑郁组和正常对照组6MWT距离分别为（259±91）nl和（312±71）nl，抑郁组步行距离短（t=3．31，P〈0．01）。抑郁组6MWT后心率、收缩压、呼吸频率、Borg指数分别为（108．2±11．3）次／min、（149±15）mmHg（1mmHg=0．133kPa）、（23．3±3．9）次／min、（4．65±1．67）分，正常对照组分别为（95±9）次／min、（142±9）mmHg、（20．2±3．7）次／min、（2．59±1．52）分，两组比较差异有统计学意义（t值分别为6．44、2．76、4．20和6．33，均P〈0．01）。结论抑郁可影响COPD患者的运动能力，治疗时不仅要关注疾病本身，同时也应关注患者心理状态对疾病的影响。
Objective To investigate the influences of depression on exercise capacity of patients with chronic obstructive pulmonary disease （COPD） in 6-minute walk test （6MWT）. Methods One hundred and twenty COPD patients, whose acute exacerbation was controlled, were enrolled in the study from September 2009 to April 2011. According to Hamilton depression scale （HAMD） scores, 48 patients with HAMD seores 〈7 were classified as non-depression group （control） , 60 patients with HAMD scores≥ 17 were classified as depression group, patients with 7≤ HAMD scores 〈 17 were classified as uncertain depression and not included in the experiment. Six-minute walk testing was performed in patients. Blood pressure, heart rates, respiratory rates, Borg scores were measured before and after 6MWT; body mass index and lung function were also measured in all patients. Results The distances of walk in the depression group and control group were （259±91） and （312 ±71） meters, respectively （P 〈0.05）. Heart rates, systolic blood pressure, respiratory rates and Borg index in depression group after testing were（ 108± 11 ）/rain, （ 148.7± 15.4） mm Hg（ 1 mm Hg =0. 133 kPa）, （23.3±3.9） /rain and （4. 65±1.67）, respectively; those for control group were （95±9） /min , （141.8_＋8.9） mm Hg, （20.2±3.7） /min and （2.59±1.52） , respectively. There were significant differences between two groups （ all P 〈 0. 05）. Conclusions Depression may affect the exercise capacity of COPD patients, the psychological status of the patients should be under consideration when conventional treatment is taken.
出处
《中华全科医师杂志》
2013年第1期40-43,共4页
Chinese Journal of General Practitioners
基金
江苏省淮安市S科技支撑计划（社会发展）（HAS2009001-3）
关键词
肺疾病
慢性阻塞性
抑郁
步行
Pulmonary disease, chronic obstructive
Depression
Walking
