摘要
目的:探讨孟鲁司特钠治疗小儿过敏性紫癜(HSP)的临床疗效。方法:96例HSP患儿随机分为治疗组和对照组各48例。两组患儿均予抗组胺药物、钙剂、维生素C治疗,并停止服用可能引起过敏的食物、药物,避免接触可疑过敏物,有感染征象的给予抗生素治疗,消化道出血者卧床休息,暂禁食,给予西咪替丁及胃粘膜保护剂,腹痛、关节肿痛者加用激素,治疗组在此基础上给予孟鲁司特钠咀嚼片口服,<10岁患儿每次5 mg,≥10岁患儿每次10 mg,每晚睡前服1次,疗程1个月。观察比较两组疗效。结果:治疗组总有效率95.8%(46/48),对照组总有效率85.4%(41/48),治疗组高于对照组,但两组总有效率比较差异无统计学意义(χ2=3.065,P>0.05);治疗组皮肤紫癜、消化道病变、关节肿痛、肾脏病变消失时间等方面均比对照组明显缩短,两组比较差异均有统计学意义(P<0.05)。结论:孟鲁司特钠治疗小儿HSP,疗效确切,能较快缓解症状、缩短病程,未发现明显不良反应,值得临床推广使用。
Objective： To explore the clinical effect of montelukast soudium in treating children with Henoch-Schnlein Purpura（HSP）.Methods： Ninety six cases of children with HSP were randomly divided into a treatment group and a control group equally.Patients in the two groups were given antihistamine drugs,calcium,vitamin C,and antibiotic treatment to those with signs of infection.All patients stopped taking food and medications that may cause allergy,and avoided contacting with suspicious allergens.Patients with gastrointestinal bleeding received cimetidine and mucosa protective agent,and had bed rest and fasting.Patients with abdominal pain,joint swelling and pain were given glucocorticoids.Based on the comprehensive therapy,the treatment group was given montelukast soudium chewing tablets,5 mg/day for 10-year-old children,10 mg /day for ≥10-year-old,once every night before bed,for one month.The effects of the two groups were observed and compared.Results： Total effective rate in the treatment group was 95.8 %,while in the control group it was 85.4 %.The effect of the treatment group was better.But there was no significant difference between the two groups（χ2=3.065,P0.05）.The durations of cutaneous purpura,gastrointestinal lesions,joint swelling and pain,renal lesions in the treatment group were significantly shorter than those in the control group.There were significant differences between the two groups（P0.05）.Conclusions： Montelukast sodium in treating children with HSP has definite effects and no adverse reactions.It can quickly relieve symptoms,shorten the course of disease,and is worthy of clinical use.
出处
《儿科药学杂志》
CAS
2013年第1期25-27,共3页
Journal of Pediatric Pharmacy
关键词
孟鲁司特钠
过敏性紫癜
小儿
疗效
Montelukast sodium
Henoch-Schonlein purpura
Children
Clinical effect
