摘要
目的探讨纳洛酮治疗老年慢性阻塞性肺病合并肺性脑病的临床效果。方法选择解放军264医院2009年10月至2011年10月慢性阻塞性肺病合并肺性脑病老年患者共70例，将患者随机分为观察组和对照组各35例。两组均给予常规治疗，观察组同时给予纳洛酮治疗。观察两组治疗前和治疗48h呼吸、心率、动脉血气分析指标的改善情况。结果观察组治疗48h的心率、血压、动脉血氧分压、动脉血二氧化碳分压分别与对照组治疗48h比较，差异有统计学意义（P〈0．05）；观察组治疗后总有效率为94．2％，对照组为74．2％，观察组显著高于对照组，差异有统计学意义（P〈0．05）。结论纳洛酮治疗老年慢性阻塞性肺病合并肺性脑病临床效果显著，值得借鉴。
Objective To investigate the clinical efficacy of naloxone in treatment of elderly chronic obstructive pulmonary disease complicated with pulmonary encephalopathy. Methods Seventy elderly cases of chronic obstructive pulmonary disease complicated with pulmonary encephalopathy were se- lected from October 2009 to October 2011, and were randomly divided into observation group and control group and 35 cases in each group. The routine therapy was used to both groups, Naloxone was given to ob- servation group. Breathing, heart rate, arterial blood gas analysis before treatment and 48 hours after treat- ment in two groups were observed. Results The heart rate, blood pressure, arterial partial pressure of ox- ygen, arterial partial pressure of carbon dioxide in observation group after treatment for 48 hours compared with those in control group after treatment for 48 hours, the difference was statistically significant （P 〈 0. 05） ;The total efficiency in observation group after treatment was 94. 2%. The total efficiency in control group after treatment was 74. 2%. The total effective rate in observation group were significantly higher than that in control group, the difference was statistically significant （ P 〈 0. 05）. Conclusions Nalox- one in the treatment of elderly chronic obstructive pulmonary disease complicated with pulmonary enceph- alopathy has significant clinical effect, and the therapy is worthy of reference.
出处
《中国实用医刊》
2013年第1期25-26,共2页
Chinese Journal of Practical Medicine
关键词
慢性阻塞性肺病
肺性脑病
老年
纳洛酮
Chronic obstructive pulmonary disease
Pulmonary encephalopathy with naloxone
Elderly
Naloxone
