摘要
目的：探讨中国人群血管紧张素转移酶（ＡＣＥ）基因多态性与原发必主胰岛素抵抗的关系。方法：采用病例对照研究方法，对祺我人群中确诊的１１２例原发性高血压和性别、年龄相匹配的健康人询问可能与原发性高血压有关的，测定空腹血糖、胰岛素，应用聚合酶链反应（ＰＣＲ）检测其ＡＣＥ基因插入／缺失（Ｉ／Ｄ）多态性。结果：病例组及男性病例组与对照组及男性对照组比较，ＡＣＥ（Ｉ／Ｄ）多态性构成均有显著差异；
Objective:To explore the association of ACE gene polymorphisms with essential hypertension and insulin resistance in Chinese population.Mothod:A population-base case-control study was carried out.Possible factors related to essential hypertension were inquired in 112 essential hypertensive patients and the same amount of sex age-matched healthy control subjects.Their fasting blood sugar,fasting blood insulin were measured.ACE gene polymorphisms were measured by using PCR method.Result:The genotype composition of ACE(I/D) polymorphisms had significant difference between the case group and the control group.Genotype DD in the case group was higher than in the control group,espically for males case group.Compare with non-obesity subjects whose ACE genotype is DD,non-obesity subjects with genotype Ⅱ,especially for males,had a higher ISI value.Conclusion:The results suggest that genetic varitaion in the ACE gene may be associated with essential hypertension and insulin resistance in Chinese population.The genotype DD of ACE gene may be an independent predictor of essential hypertension,espically for men;and it could be a genetic linkage of essential hypertension.The non-obosity subjects with genotype Ⅱ of ACE gene,males in particular,are liable to insulin resistance.
出处
《医师进修杂志》
2000年第7期18-20,共3页
Journal of Postgraduates of Medicine
关键词
基因多态性
原发性高血压
胰岛素抵抗
ACE
angiotensin converting enzyme
gene polymorphism
essential hypertension
male
insulin resistance
