摘要
目的总结雷帕霉素靶蛋白(mTOR)及其信号通路在胃癌化疗耐药中的研究现状。方法查阅国内外近年来有关mTOR信号通路在胃癌化疗耐药中作用机理的文献并做综述。结果 mTOR作为mTOR信号转导通路中一个重要的信号分子,参与了细胞的生长、增殖以及代谢,血管新生等重要过程。mTOR信号通路相关分子在胃癌中过表达,在胃癌的化疗耐药中起重要作用。此外,肿瘤干细胞也参与了胃癌的化疗耐药。结论 mTOR及其信号通路在胃癌的化疗耐药中起重要作用。以mTOR为靶点,联合应用mTOR抑制剂和化疗药物治疗胃癌,对克服胃癌化疗耐药已初见成效,具有广阔的临床应用前景。
Objective To review the role of mTOR signal pathway in chemo-resistance of gastric cancer.Methods Domestic and international publications related mTOR signal pathway in chemo-resistance of gastric cancer in recent years were collected and reviewed.Results mTOR was a central signaling molecule of mTOR signal pathway,which regulated key cellular processes such as cell growth,cell proliferation,cell metabolism,and angiogenesis.Signaling molecules of mTOR signal pathway were overexpressed in gastric cancer.Moreover,mTOR signal pathway might play an important role in chemo-resistance of gastric cancer,and tumor stem cells were involved in it too.Conclusion As mTOR signal pathway plays an important role in chemo-resistance of gastric cancer,the combination of mTOR inhibitors and chemotherapy drugs may overcome the chemo-resistance of gastric cancer.
出处
《中国普外基础与临床杂志》
CAS
2012年第12期1352-1356,共5页
Chinese Journal of Bases and Clinics In General Surgery
基金
国家自然科学基金资助项目(项目编号:81101850)
上海市教委基金资助项目(项目编号:12YZ047)~~
关键词
雷帕霉素靶蛋白
胃癌
肿瘤干细胞
化疗耐药
Mammalian target of rapamycin
Gastric cancer
Tumor stem cell
Chemo-resistance
