摘要
肿瘤的进展和转移不仅与肿瘤自身的特性有关,还与肿瘤所处的微环境密不可分。肿瘤相关巨噬细胞(tumor-associatedmacrophages,TAMs)是肿瘤微环境中数量最多的肿瘤相关炎性细胞,在不同的信号刺激下可分化成抗肿瘤的M1型巨噬细胞或促肿瘤的M2型巨噬细胞。在许多恶性肿瘤中,TAMs被证实参与了肿瘤的进展和转移,M2型巨噬细胞较多。然而在结直肠癌中,大部分研究却得出了相反的结论,认为TAMs促进了炎症的发展,抑制了肿瘤的进展和转移。但一些体内和体外实验却发现TAMs促进了结肠癌的增殖和转移,M2型巨噬细胞居多。此外,还有研究发现在结直肠癌中TAMs的功能随位置、肿瘤分期的不同而变化,而且并不以单纯的M1或M2形式存在,往往同时表现出M1和M2的一些特点。本文就TAMs在结直肠癌中的研究现状做一综述,以期全面了解TAMs在结直肠癌中的作用,为进一步深入研究二者的关系提供线索。
It has become increasingly apparent that cancer progression and outcome is not solely dependent on the characteristics of the tumor but on the tumor microenvironment as well. Tumor-associated macrophages （TAMs）, which constitute a significant part of the tumor-infiltrating immune ceils, are ＂educated＂ towards an anti-tumor M1 phenotype or pro-tumor M2 phenotype by different signals of the tumour microenvironment.Whereas the vast majority of studies with numerous tumor types show that the presence of TAMs in the tumor microenvironment is associated with a worse prognosis, which suggests polarization of TAMs towards the M2 phenotypes, most studies in colorectal cancer claim the opposite, suggesting the polarization of TAMs towards the M1 phenotype, Meanwhile, some in vivo and in vitro experiments have found that TAMs promote the proliferation and metastasis ofcolorectal cancer. Some other studies have found that tumor microenvironment can induce the functional polarization of macrophages toward a mixed M1/M2 phenotype, and that the function of TAMs could be changed with their location and stage of tumor. In this review, we summarize the different and controversial effects that TAMs play in colorectal cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2012年第24期2121-2124,共4页
Chinese Journal of Clinical Oncology
基金
supported by grants from the Scientific Project of Tianjin Medical University(No.2008KY34)
