摘要
目的:探讨分化型甲状腺癌是否为女性激素依赖性肿瘤,分析ER、PR的表达与分化型甲状腺癌患者的肿瘤大小、组织学类型、有否淋巴结转移、性别、年龄等的关系。方法:应用免疫组织化学方法(SP法)检测分析正常甲状腺、甲状腺良性肿瘤和分化型甲状腺癌组织中ER、PR的表达。结果:分化型甲状腺癌中ER和PR阳性表达分别为19.3%(10/52)和30.8%(16/52),其表达比正常甲状腺与良性肿瘤组织多,有显著性差异(P<0.01)。分化型甲状腺癌的肿瘤直径>1 cm的ER、PR阳性率明显高于≤1 cm的病例,有显著性差异(P<0.01)。而ER和PR的表达与患者的性别、年龄、组织类型和淋巴结转移无关。结论:分化型甲状腺癌组织中ER和PR的表达较正常甲状腺、甲状腺良性肿瘤组织高,有显著差异性(P<0.01),且肿瘤直径>1 cm者的ER和PR表达高于肿瘤直径≤1 cm者,揭示分化型甲状腺癌可能是雌激素和孕激素依赖性肿瘤。
Objective： ATo investigate whether differentiated thyroid carcinoma （DTC） is a hormone-dependent neoplasm, and analyze the relationship between the expressions of ER/PR in DTC with tumor size, histology types, lymph node metastasis, and gender, age. Methods： To detect the expression of estrogen receptor（ER）/Progesterone Receptors（PR） in normal thyroid tissue, thyroid benign tumor, and DTC by using the immunohistochemical staining technique （SP method）. Results： There was no expression of ER/PR in most cases of normal thyroid tissue and benign tumor. The positive rates of ER/PR were 19.3% （10/52）/30.8% （16/52） in DTC. The positive rate of ER/ PR was significantly higher in DTC than in the normal thyroid tissue, nodular goiter, and follicular adenoma; there was a significant difference among them （P〈0.01）. The positive rate of ER/PR in cases of tumor with diameter of more than 1 cm was significantly higher than those of tumor with diameter of not more than 1 cm; there was a significant difference between them （P〈0.01）. However, the expression positive rate of ER/PR in DTC was related to gender, age, histology types, and lymph node metastasis. Conclusion： The positive rate of ERfPR in DTC was higher than those in normal thyroid tissue, nodular goiter, and follicular adenoma; there was a statistical significance among them （P〈0.01）. The positive rate of ER/PR in cases of tumor with diameter of more than 1 cm was significantly higher than those of tumor with diameter of not more than 1 cm. The result suggested that DTC may be a kind of estrogen/progesterone-dependent neoplasm.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2012年第24期2091-2093,共3页
Chinese Journal of Clinical Oncology
基金
2004年中山市科技局科研项目(编号:2004A075)资助~~
关键词
分化型甲状腺癌
雌激素受体
孕激素受体
免疫组织化学
Differentiated thyroid carcinoma
Estrogen receptor
Progesterone receptor
Immunohistochemistry
