摘要
目的：探讨胃癌患者血甭透明质酸（ＨＡ）、Ⅲ型前胶原肽（ＰⅢＰ）、Ⅳ型胶原（Ⅳ－Ｃ）、层粘连蛋白（ＬＮ）含量及临床意义。方法：采用放射免疫技术测定了４８你胃癌患者ＨＡ、ＰⅢＰ、Ⅳ－Ｃ、ＬＮ含量，并以消化性溃疡用正常健康组作为对照。结果：胃癌组血清ＨＰ、ＰⅢＰ、Ⅳ－Ｃ、ＬＮ含量显著高于正常组，Ｐ〈０．０１～０．００１，肝转移组高于肝未转移组，Ｐ〈０．０５～０．０１，胃癌组ＨＡ、ＰⅢＰ高于消化性溃疡组，
Objective:To assess serum hyaluronic acid (HA),type Ⅲ procollagen peptide (PⅢP),tyep Ⅳ collagen (Ⅳ-C) and laminin (LN) levels in gastric cancer patients.Methods:Serum HA,PⅢP,Ⅳ-C,LN were detected by radioimmunoassay in gastric cancer (n=48),peptic ulcer (n=51) and healthy control (n=50).Results:The HA,PⅢP,Ⅳ-C,LN level were significantly increased in gastric cancer patients in comparison with healthy controls (P<0.01～ 0.001 ).Gastric cancer patients with hepatic metastasis had significantly higher serum HA,PⅢP,Ⅳ-C,LN levels than those without hepatic metastasis,P<0.05～0.01.The content of HA,PⅢP in gastric cancer patients were significantly higher than those in peptide ulcer patients.Conclusions:The results suggest that the detection of HA,PⅢP,Ⅳ-C and LN in serum might be useful for diagnosis of hepatic metastasis of gastric cancer.
出处
《医师进修杂志》
2000年第6期20-21,共2页
Journal of Postgraduates of Medicine
