摘要
目的 通过对经手术后病理证实的 16 2例库欣综合征患者临床资料的分析 ,进一步认识类固醇性糖尿病的特点。方法 回顾性分析库欣患者的发病年龄 ,库欣病程 ,体重指数 (BMI) ,2 4h尿游离皮质醇浓度 (2 4hUFC) ,病理结果 ,手术前后空腹血糖水平 ,糖尿病家族史 ,术前及术后糖代谢异常的治疗等。结果 患有继发糖尿病的库欣患者发病年龄及库欣病程明显高于血糖正常组。而 BMI与 2 4h UFC两组患者差异无显著意义。除肾上腺癌外两组病理类型差异无显著意义。糖代谢异常患者术后空腹血糖水平明显低于术前。术后大部分糖尿病患者停用了药物治疗。仅一例继发糖尿病患者家族史阳性。结论 高龄发病及病程长的库欣患者易出现糖代谢异常 ,糖尿病家族史、向心性肥胖、尿皮质醇水平及库欣的良性病理类型似与发生糖代谢异常无关。继发性糖尿病的治疗重点应是原发病的根治。
To understand the characteristic of steroid diabetes by the analysis for clinical data of 162 cases with Cushing syndrome(CS) proved by pathological report. Methods Retrospective analysis for the data of CS about age of CS onset,duration of CS,body mass index(BMI),24 hours urine free cortisol(24 h UFC),pathological report,fasting blood glucose(FBG) pre-and post-operation, family history of diabetes,treatment of glucose dysbolism(GD) pre-and post-operation. Results The onset age and duration of CS in GD group was obviously earlier and longer than normal glucose(NG) group.BMI and 24 h UFC were no differance between two groups.Besides adrenal adenocarcinoma,no differance was found in types of pathology.FBG of diabetes pre-operation was obviously lower than post-operation.After operation,most diabetes need not on drug treatment.Only one secondery diabetes has family history. Conclusions Steroid diabetes easily occurs in patients who is senility and suffer longer course of CS.No relation to diabetic family history, concentric obesity,the level of UFC and benign types of pathology.Therapeutical emphasis of steroid diabetes is radical cure of CS.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2000年第3期266-268,共3页
Acta Academiae Medicinae Sinicae
