摘要
更深入和全面地评价巴戟天水提物的抗抑郁作用。方法 :采用大鼠低速率差式强化程序 (DRL 72s)和小鼠强迫性游泳法。结果 :在大鼠DRL 72s模型上 ,巴戟天水提物 50mg/kg与抗抑郁剂地昔帕明 5mg/kg的作用一致 ,均显著增加大鼠DRL 72s的强化数 ,减少反应数和降低效应比率。在小鼠强迫性游泳模型上 ,巴戟天水提物 50mg/kg与地昔帕明 2 0mg/kg和阿米替林2 0mg/kg的作用类似 ,明显缩短小鼠的不动时间 ,巴戟天水提物 2 5mg/kg也具有缩短小鼠不动时间的趋势。同时 ,巴戟天水提物在有效缩短小鼠不动时间的剂量 ( 2 5～ 50mg/kg)时不影响小鼠自发活动性。结论 :进一步表明巴戟天水提物具有抗抑郁作用。
Objective:To evaluate deeply and comprehensively antidepressant effect of an aqueous extract of Morinda officinalis How. Methods: Differential reinforcement of low rate 72 second schedule (DRL 72 s) in rats and the forced swimming test in mice were used. Results: In the DRL 72 s, the aqueous extract of M.officinalis 50 mg/kg, similar to clinically effective antidepressant desipramine 5 mg/kg,significantly reduced responses and efficiency ratio and at the same time increased number of reinforcement. In the forced swimming test, the aqueous extract 50 mg/kg, like the effect of desipramine 20 mg/kg and amitriptyline 20 mg/kg, elicited significant decrease in immobility time. A tendency to this phenomenon also could be seen at the dose of 25 mg/kg. At the same time, the aqueous extract at the effective doses for the forced swimming test (25～50 mg/kg) had no effect on spontaneous motor activity in mice. Conclusions: These findings further support the conclusion that the aqueous extract of M.officinalis possesses antidepressant like effect. [
出处
《军事医学科学院院刊》
CSCD
北大核心
2000年第2期114-117,共4页
Bulletin of the Academy of Military Medical Sciences
关键词
巴戟天水提物
低速率差式强化
强迫性游泳
aqueous extract of M.officinalis
desipramine
amitriptyline
differential reinforcement of low rate 72 s schedule
forced swimming test
