摘要
一氧化氮是生物体内重要的信使分子和效应分子 ,参与多种生理功能的调节 ,在胃肠道系统中具有保护胃粘膜的作用。将一氧化氮供体引入到传统的非甾体抗炎药结构中是近年来解决传统非甾体抗炎药胃肠道副作用问题的热点之一。
Nitric oxide(NO), an important biological messenger and effector molecule,is involved in the regulation of various physiologic functions and exerts the protective effect on gastrointestinal tract. The combination of NO donors with classic nonsteroidal antiinflammatory drugs(NSAIDs) is one of the approaches to reduce the gastrointestinal damage induced by classic NSAIDs. The review briefly describes the advances in the research of NONSAIDs.
出处
《药学进展》
CAS
2000年第3期145-148,共4页
Progress in Pharmaceutical Sciences
关键词
一氧化氮
一氧化氮供体型
非甾体抗炎药
Nitric oxide(NO)
NO-NSAIDs
Gastrointestinal protective effect
