摘要
通过对使用补肾加和解法中药治疗再障患者 ,观察其血清 TNF- α及 r- IFN治疗前后水平的变化 ,并与西药对照组及正常对照组进行比较 ,以探讨药物作用机制。结果表明 ,实验组治疗前 2种细胞因子水平较正常对照组明显增高 ,经治疗后 ,实验组较治疗前明显降低 ,说明补肾加和解法对再障患者这两种细胞因子有调节作用 ,笔者推测补肾加和解法中药是通过降低造血负调节因子 TNF- α和 r- IFN水平 ,而减轻了对造血的抑制作用。实验还表明 ,治疗前的阳虚型血清 TNF- α和 r- IFN水平明显比阴虚型低 ,说明阳虚型和阴虚型是有一定的物质基础的 ,治疗后阳虚型血清 TNF- α和 r- IFN水平较阴虚下降的快 ,这也许可能与免疫损伤相对轻有关。
Through the observation to the changes of TNF α and r IFN in patients' blood serum before and after the treatment with invigorating the kidney and harmorizing method.We compared the contrast group of western medicine with the normal contrast group in order to probe the function of medicine.The results showed that the cell factor in experimental group was much higher than that of normal contrast group before treatment.After treatment it became lower than that of experimental group.These indicated that invigoratnig the kidney and harmorizing method could regulate the function of cell factors of patients with aplastic anemia.We supposed our method reduce inhibiting function of blood-making by decreasing TNF α and r IFN level of blood making negative regulation.The result also showed that TNF α and r IFN level of deficiency of yang blood serum was lower than that of deficiency of yin.It proved that dificiency of yang and deficiency of yin had certain substance fundation.TNF α and r IFN level of deficiency of yang blood serum decreased quicker than that of deficiency of yin.This maybe has some relationship with slight immune damage.
出处
《辽宁中医杂志》
CAS
北大核心
2000年第4期165-166,共2页
Liaoning Journal of Traditional Chinese Medicine
基金
:空军"95"医药卫生重点课题! (A)类 (A2 8)
关键词
再生障碍性贫血
中医药疗法
TNFΑ
干扰素
invigorating the kidney and harmonizing method
tumour nicrotic factor
interferon
