摘要
目的探讨三维能量多普勒超声在宫颈癌动脉化疗栓塞疗效预测中的应用价值。方法对26例病理证实的宫颈癌患者分别于动脉化疗栓塞前及化疗栓塞后4周行三维能量多普勒超声检查,测定肿瘤体积及肿瘤内血管形成指数(VI)、血流指数(FI)、血管形成-血流指数(VFI)3项血管参数值,并记录肿瘤的临床病理特征;化疗后4周依据国际抗癌联盟疗效判断标准将患者分为有效组和无效组,比较两组患者化疗栓塞前肿瘤体积及肿瘤内部血管参数的差异,研究肿瘤体积及肿瘤内部血管参数与动脉化疗栓塞疗效间的关系。结果 26例宫颈癌患者动脉化疗栓塞后,完全缓解2例,部分缓解18例,病情稳定4例,病情进展2例,动脉化疗栓塞有效率为76.9%(20/26),无效率为23.1%(6/26);有效组化疗前肿瘤体积、VI、FI及VFI分别为(40.3±23.2)ml、(5.4±3.5)%、40.9±4.3和2.3±1.6;无效组化疗前肿瘤体积、VI、FI及VFI分别为(30.2±20.8)ml、(11.3±4.2)%、44.0±3.9和5.1±2.2;无效组化疗前VI及VFI明显高于有效组相应血管参数值,差异有统计学意义(P<0.05),而两组间肿瘤体积及FI比较差异均无统计学意义。结论三维能量多普勒超声获得的血管参数在宫颈癌动脉化疗栓塞疗效预测中有一定的临床应用价值。
Objective To evaluate the potential role of three-dimensional （3D） power Doppler ultrasound in predicting response to transarterial chemoembolization（TACE） on cervical cancer. Methods Twenty-six women with cervical cancer treated by TACE followed by surgery were enrolled. Clinical characteristics and pathologic data were recorded. 3D power Doppler ultrasound was performed before and after TACE. The vascularization index （ VI ）, flow index （ FI ） and vascularization flow index （VFI） within the tumor were recorded and used for analysis. All patients were clinically evaluated by physical examination and 3D power Doppler ultrasound after TACE. Their response to TACE was evaluated. Results Of 26 patients （responders）, 20 of them （76.9%）showed a response to TACE and including 2 cases of complete remission and 18 cases of partial remission, 4 of them （23.1% ） were in a stable condition and 2 of them progressed （ nonresponders ） after TACE. The tumor volume, VI, FI and VFI of the responders before TACE were （40.3±23.2） ml, （5.4±3.5）%, 40.9±4.3 and 2.3±1.6, respectively. The tumor volume, VI, FI and VFI of the nonresponders before TACE were （30.2±20.8） ml, （ 11.3±4.2）%, 44.0±3.9 and 5.1±2.2, respectively. VI and VFI of the nonresponders before TACE were significantly higher than those of the responders. No differences were found in tumor volume and FI. Conclusion The power Doppler vascularity index can predict the response to TACE in cervical cancer and might be useful for the evaluation of response to TACE in cancer patients in the future.
出处
《临床超声医学杂志》
2012年第12期801-804,共4页
Journal of Clinical Ultrasound in Medicine
关键词
超声检查
多普勒
能量
三维
动脉化疗栓塞
宫颈癌
Uhrasonography, Doppler, power
Three-dimensitonal
Transarterial chemoembolization
Cervical cancer
