摘要
目的：探讨近年来前列腺癌筛查的研究进展和发展趋势。方法：使用Pubmed以及万方等检索工具检索近年来前列腺癌筛查方面的相关文献，总结前列腺癌筛查的最新研究进展及未来发展趋势。结果：为达到切实、有效的诊断目的，从而对筛查的必要性以及更为精准的血清前列腺特异性抗原（PSA）筛查阈值进行了大量研究和探索，同时也对血清PSA衍生物以及其他更具特异性的筛查标记物进行了系列研究和探索。结论：血清PSA及其衍生物虽然应用较为广泛，但因其不具有前列腺癌组织特异性，致使筛查结果存在误差。所以寻找敏感性更高且具有前列腺癌组织特异性的标记物是未来前列腺癌筛查研究的重要趋势之一。
Objective：To systematically investigate recent researches of prostate cancer screening and discuss its future development trend. Methods：To retrieve and summarize the relevant research papers in the area of prostate cancer screening in recent years through Pubmed, Wanfang and other searching tools. The fu- ture development trend of prostate cancer screening researches was discussed. Results： In order to achieve the purpose of practicality and effectivity in clinical diagnostic, plenty of researches were done on the necessity of screening, more accurate serum prostate specific antigen （PSA） screening threshold, and also on serum PSA derivatives and other more specific screening biomarkers. Conclusions：Although serum PSA and its derivativesare widely used in prostate cancer screening, they are not specific expressed in prostate cancer tissues, which can re- sult in the detecting error of prostate cancer screening. Therefore, it suggests that one important development trend of prostate cancer screening can be searching new biomarkers for prostate cancer screening with higher sensitivity and specificity in prostate cancer tissues.
出处
《解剖与临床》
2012年第6期530-533,共4页
Anatomy and Clinics
关键词
前列腺癌
筛查
前列腺特异抗原
标记物
Prostate cancer
Screening
Prostate specific antigen
Biomarkers
