摘要
目的研究云南省晋宁县彝族人群AGT基因M235T多态性分布的情况,为进一步控讨AGT基因相关性疾病的发病机制奠定基础.方法采用PCR-RFLP技术对居住在云南省晋宁县173例彝族健康个体的AGT基因M235T多态性进行分析,获得其基因型频率和等位基因频率分布情况.并与其他人群该位点多态性进行比较.结果云南省晋宁县彝族AGT基因的MM、MT、TT基因型频率分别为7.51%、39.31%和53.18%,M和T等位基因频率分别为27.17%和72.83%.此位点多态性分布与不同人群比较,除汉族外,差异均有统计学意义(P<0.01).结论 AGT基因M235T多态性分布存在民族、种族差异.
Objective To investigate the angiotensinogen（AGT）gene M235T polymorphism in a Yi nationality population of Yunnan province,and to provide evidence for the research of AGT related diseases.Methods We recruited 173 healthy subjects of Yi nationality in rural area of Jinning,Yunnan province.The AGT M235T polymorphism was determined by polymerase chain reaction-restriction fragment（PCR-RFLP） technique.The genotype frequencies and allele frequencies were obtained and compared with those were collected from other population.Results In healthy Yi people of Yunnan province,frequencies for the MM,MT and TT genotypes were 7.51%,39.31% and 53.18%,respectively.Derived allele frequencies for the M and T allele were 27.17% and 72.83%,respectively.The distribution of AGT genotypes and the allele frequencies in Yunnan Yi people were similar to Han population（P0.05）,while were significantly different from that in other nationalities（P0.01）.Conclusion The distribution of AGT M235T polymorphism is different significantly in different ethnic populations.
出处
《昆明医科大学学报》
CAS
2012年第11期4-7,共4页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81160164)
云南省自然科学基金资助项目(2008CD117)
关键词
AGT基因
遗传多态性
彝族
分布
AGT gene
Genetic polymorphism
Yi nationality
Distribution
