摘要
目的:回顾分析使用氯吡格雷进行药物治疗的老年冠心病患者行多次PCI术的影响因素。方法:选择2011年1–12月在卫生部北京医院住院的50名行两次及以上PCI术且术后均常规使用氯吡格雷进行抗血小板治疗的老年冠心病患者;详细调查患者的一般情况和临床用药情况,根据其行PCI术的频次分成两组(2次PCI术时间间隔在1年内和1年以上),采用χ2检验进行单因素分析,再用Logistic回归进行多因素分析,考察各因素对1年内行多次PCI术的影响。结果:单因素分析结果显示,患者年龄、BMI值、吸烟、硝酸酯类药物、合并高脂血症与老年冠心病患者1年内行多次PCI术有一定的相关性(P<0.15);多因素分析结果显示,年龄与合并高脂血症是老年冠心病患者1年内行多次PCI术的独立相关因素(P<0.05)。结论:老年冠心病患者应注意控制血脂水平,70岁以上患者是1年内行多次PCI术的高危人群,应予以关注。
Objective： To retrospectively analyze the influencing factors of repeated PCIs in elderly patients with coronary artery disease under the treatment of clopidogrel. Methods： Fifty elderly inpatients with coronary artery disease in Beijing Hospital from January 2011 to December 2011 who had more than twice PCI operations and were all treated with clopidogrel after surgeries were included. The basic characteristics and clinical treatment information of patients were investigated, and patients were divided into 2 groups according to the frequency of PCI （interval between two times of PCIs less than one year versus more than one year）. The chi-square test was used for univariate analysis, and logistic regression was used for multivariate analysis to investigate the impact of various factors on repeated PCIs in one year. Results： Univariate analysis showed that age, BMI, smoking, treatment with nitrates and hyperlipidemia were related with repeated PCIs in one year in elderly patients with coronary artery disease （P 〈 0.15）. Multivariate analysis showed that age and hyperlipidemia were independent risk factors associated with repeated PCIs in one year in those patients （P 〈 0.05）. Conclusion： Elderly patients should pay attention to controlling lipid levels, and elderly patients more than 70 years old are high-risk of repeated PCIs in one year, which should be paid close attention to.
出处
《中国药物应用与监测》
CAS
2012年第6期317-320,331,共5页
Chinese Journal of Drug Application and Monitoring
基金
卫生行业科研专项项目(201002011)
关键词
氯吡格雷
老年患者
PCI术
冠心病
Clopidogrel
Elderly patient
Percutaneous coronary intervention
Coronary heart disease
