期刊文献+

小儿肺炎与降钙素原、C反应蛋白和白细胞的关系 被引量:6

The Clinical Significance of Serum Procalcitonin, C-reactive Protein and White Blood Cell in Children with Pneumonia
暂未订购
导出
摘要 目的探讨血清降钙素原(PCT)、C反应蛋白(CRP)、白细胞(WBC)在小儿肺炎患儿病情评估中的临床意义。方法随即选取121例肺炎患儿,其中细菌性肺炎59例(组A),病毒性肺炎62例(组B),测定两组患儿血清PCT、CRP、WBC值,比较三个指标鉴别细菌性肺炎和病毒性肺炎的敏感性和特异性。结果 PCT在诊断细菌性肺炎时敏感性为85.9%,特异性为92%,CRP诊断细菌性肺炎时敏感性为59.2%,特异性为88%,WBC诊断细菌性肺炎时敏感性为70.4%,特异性为62%。结论血清降钙素原水平有助于小儿肺炎的鉴别诊断,并较CRP和WBC具有较高的敏感性和特异性。 Objective To detect the clinical value of the levels of serum procalcitonin(PCT),C-reactive protein(CRP) and white cell count(WBC) in children with pneumonia.Methods 121 children with pneumonia were divided randomLy into bacterial pneumonia group(group A,n=59) and virus pneumonia group(group B,n=62).PCT,CRP and WBC levels were detected in all cases.Compare the sensitivity and specificity of three indicators in discriminating bacterial pneumonia and virus pneumonia.Results Sensitivity of PCT in diagnosing bacterial pneumonia was 85.9%,and specificity was 92%.Sensitivity of CRP in diagnosing bacterial pneumonia was 59.2%,and specificity was 88%.Sensitivity of WBC in diagnosing bacterial pneumonia was 70.4%,and specificity was 62%.Conclusions PCT is a valuable indicator in the diagnosis of bacterial pneumonia in children and has higher sensitivity and specificity than CRP and WBC.
出处 《中国医药指南》 2012年第35期400-401,共2页 Guide of China Medicine
关键词 降钙素原 小儿 细菌性肺炎 Procalcitonin Children Bacterial pneumonia
  • 相关文献

参考文献6

二级参考文献16

  • 1王瑾,张蓉,邵肖梅.降钙素原在新生儿感染中的应用价值[J].临床儿科杂志,2005,23(2):105-107. 被引量:57
  • 2杨公炜,汪明明,徐皖苏.血清降钙素原检测在临床中的应用[J].医学综述,2005,11(9):841-843. 被引量:43
  • 3盛瑶.降钙素原C反应蛋白在新生儿败血症早期诊断的意义[J].浙江临床医学,2007,9(3):388-389. 被引量:22
  • 4黄骋,邱慧宝,陈鸿恩,李红,尹建军,李蓉,孙静.降钙素原(PCT)在儿科感染性疾病诊断中的应用[J].赣南医学院学报,2007,27(1):82-83. 被引量:3
  • 5Muller B,White J C, Nylen E S,et al. Ubiquitous expression of the ealeitonin 1 gene in multiple tissues in response to sepsis [J] J Clin Endoerinol Metab, 2001,86( 1 ) : 396 - 404.
  • 6Charles P E, Ladoire S,Aho S,etal. Serum procalcitonin eleva- tion in critically ill patients at the onset of bacteremia caused by either gram negative or gram-positive bacteria[J]. BMC In fect Dis, 2008,8,38.
  • 7Keshet R,Boursi B,Maoz R,et al.Diagnostic and prognostic significance of serum C-reactive protein levels in patients admitted to the department of medicine[J].Am J Med Sci,2009,337(4):248-255.
  • 8Liao H,Wu J,Kuhn E,et al.Use of mass spectrometry to identify protein biomarkers of disease severity in the synovialfluid and serum of patients with rheumatoid arthritis[J].Arthrit Rheum,2004,50(11):3792-3803.
  • 9Reny JL,Vuagnat A,Raet C,et al.Diagnosis and follow-up of infections in intensive care patients:Value of C-reactive protein compared with other clinical and biological variables[J].Crit Care Med,2002,30(3):529-535.
  • 10Whang KT,Vath SD,Becker KL,et al.Procalcitonin and proin-flammatory cytokine interactions in sepsis[J].Shock,2000,14(1):73-78.

共引文献61

同被引文献45

  • 1诸福棠 吴瑞萍.实用儿科学[M].北京:人民卫生出版社,1994..
  • 2Karzai W, Oberhoffer M, Meier-Hellmann A, et al. Procalcitonin-A new indicater of the systemic Response to severe inections[J]. Infection, 1997 , (6) : 329-334:
  • 3Maruna P, Nedelnikovd K, Gtirlich R. Physiology and genetics of procalcitonin[J]. Physiol Res, 2000,49 (Suppl 1) : S57-S61.
  • 4Zhang Q,Guo Z,Bai Z, et al. A 4 year prospective study todetermine risk factors for severe community acquired pneumoniain children in southern China [ J]. Pediatr Pulmonol,2013,48(4): 390 -397.
  • 5Tasdelen FN, Aliyazicioglu Y,Coban Y,et al. The value ofneopterin and procalciton in in patients with sepsis [ J]. SouthMedcine,2010,103(3) :216 -219.
  • 6Okeke EB,Okwor I, Mou Z,et al. CD4 + CD25 + Regulatory TCells Attenuate Lipopolysaccharide - Induced SystemicInflammatory Responses and Promotes Survival in MurineEscherichia coli Infection[ J]. Shock,2013 ,40( 1) :65 -73.
  • 7Miller MM, Fogle JE,Ross P, et al. Feline glycoprotein Arepetitions predominant anchors transforming growth factor betaon the surface of activated CD4 + CD25 + regulatory T cells andmediates AIDS lentivirus - induced T cell immunodeficiency[J]. AIDS Res Hum Retroviruses, 2013 ,29 ( 4) :641 -651.
  • 8Santos AA Jr, Rodrigues - Junior V,Zanin RF,et al.Implication of purinergic P2X7 receptor in M. tuberculosisinfection and host interaction mechanisms : A mouse modelstudy [J]. Immunobiology, 2013 ,218(8) :1104 - 1112.
  • 9吴越,周晓玉.与维生素D相关的临床疾病研究进展[J].中国实用儿科杂志,2010,25(1):68-70. 被引量:28
  • 10陈自武.降钙素原、超敏C反应蛋白与外周血碱性磷酸酶积分在细菌感染中应用探讨[J].临床和实验医学杂志,2010,9(8):572-573. 被引量:24

引证文献6

二级引证文献33

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部