摘要
目的探讨2型糖尿病非糖尿病一级亲属高危人群血清铁蛋白的临床意义。方法将糖尿病患者、糖耐量异常者、糖耐量正常的一级亲属、无糖尿病家族史且糖耐量正常者分为A、B、C、D四组;对所有受试者进行血清铁蛋白(SF)、OGTT、胰岛素释放试验等,用稳态模型(HOMA)公式来评估胰岛抵抗(IR)和胰岛素分泌功能。结果 (1)男性铁蛋白含量明显高于女性;(2)血清铁蛋白测定值由高到低次序是A、B、C、D组;(3)A、B、C组分别于D组比较,P<0.01。结论 SF升高有可能是早期糖代谢紊乱的有效预报因子,检测SF有助于更早发现潜在的糖尿病患者。
Objective To explore the clinical meaning of serum ferritin of nondiabetic first-degree relatives high risk group of type 2 diabetes mellitus（T2DM）.Methods Patients with diabetes,impaired glucose tolerance,first-degree relatives with normal glucose tolerance and normal glucose tolerance without family history of diabetes were divided into group A,B,C,D;SF,OGTT and Insulin release test were made for all subjects,and steady-state model formula（HOMA） was used to e valuate insulin resistance（IR） and secretory function of insulin.Results（1）Male ferritin content was obviously higher than that of female;（2）The measured values of serum ferritin ranked from high to low：group A,group B,group C,group D;（3）group A,B and C were compared with group D,P 〈0.01.Conclusion SF may be an effective predictor of disturbance of early carbohydrate metabolism.Detection of SF can helps to earlier find potential diabetic patients.
出处
《中国当代医药》
2012年第35期36-37,共2页
China Modern Medicine
关键词
糖尿病
铁蛋白
一级亲属
血清
Diabetes mellitus
Ferritin
First-degree relatives
Serum
