摘要
目的 评价西咪替丁对经内镜逆行胰胆管造影 (ERCP)术后高淀粉酶血症及急性胰腺炎的预防作用。方法 将 414例患者随机分为A、B、C三组 ,A组 (15 8例 )分别于术前一日、当日及术后一日给予西咪替丁 (80 0mg/d ,静脉滴注 ) ,B组 (147例 )分别于术前 30min及术后 4h内给予生长抑素类似物奥曲肽 0 1mg皮下注射 ,C组 (10 9例 )给予安慰剂。术前、术后 3h及 2 4h检测血清淀粉酶 (正常参考值 10～ 12 0U/L)及肝、肾功能。结果 A组有 5例 (3 16 % )、B组 4例 (2 72 % )和C组 9例 (8 30 % )发生急性胰腺炎 (A组与C组比较 ,P <0 0 5 ;B组与C组比较 ,P <0 0 5 ;A组与B组比较 ,P >0 0 5 )。A组有 39例 (2 4 70 % )、B组 37例 (2 5 17% )和C组 5 8例 (5 3 2 1% )发生高淀粉酶血症 (A组与C组比较 ,P <0 0 1;B组与C组比较 ,P <0 0 1;A组与B组比较 ,P >0 0 5 )。
Objective The preventive effect of cimetidine on post-ERCP pancreatitis and hyperamylasemia was investigated Methods 414 patients who underwent ERCP were divided at random into 3 groups; group A (n=158) receiving perioperative intravenous cimetidine, 800mg/day for 3 days; group B (n=147) having hypodermic octreotide, 0 1mg, 30 minutes before and 4 hours after ERCP; group C (n=109) being given boluses of placebo Blood was drawn in each group the day before, 3 hours and 24 hours following ERCP for amylase and hepatorenal functions Results Post-ERCP pancreatitis ensued in 5 (3 16%) cases of group A; in 4 (2 72%) of B and 9 (8 30%) of C ( P < 0 05 when A vs C and B vs C; P >0 05 while A vs B) Hyperamylasemia occurred in 39 (24 70%) instances of group A, in 37 (25 17%) of B and 58 (53 21%) of C, ( P < 0 01 as A vs C and B vs C, whereas P >0 01 as A vs B) Conclusion Cimetidine exerts the same preventive effect as octreotide on ERCP against pancreatitis and hyperamylasemia
出处
《中华消化内镜杂志》
2000年第2期81-83,共3页
Chinese Journal of Digestive Endoscopy
