摘要
目的探讨肿瘤相关AAA＋核共调解蛋白（ATAD2）在胃癌组织中的表达及意义。方法应用免疫组化SP法检测ATAD2在76例胃癌标本及13例正常胃组织中的表达，并结合临床病埋参数分析其相关性。结果ATAD2在胃癌组织中的表达水平明显高于正常组织（0．0913±0．0322与0．0482±0．0085，P〈0．05）。胃癌组织中ATAD2蛋白表达与淋巴结转移与否、肿瘤病理分级存在相关性（P〈0．05），与患者的性别、年龄无关（P〉0．05）。结论胃癌组织中ATAD2的表达增高与胃癌的发展过程密切相关，可能成为反映胃癌恶性生物学行为和诊治的一个指标。
Objective To investigate the expression, correlation and clinical significance of TAD2 in gastric carcinoma. Methods The expression of ATAD2 in 76 gastric carcinoma and 13 normal gastric tissue was examined by S-P immunohistochemistrical staining, and the correlation of ATAD2 ex- pression and clinicopathological parameters was analyzed. Results The expression of ATAD2 in gastric carcinoma was obviously higher than that in normal gastric tissue （0.0913 ± 0.0322 vs 0. 0482 ±0.0085, P 〈 0.05 ）. Increased expression of ATAD2 was significantly associated with lymph node metastasis and advanced pTNM stage, while it was not associated with age and gender. Conclusion Increased expression of ATAD2 may contribute to the development of gastric carcinoma, and might be a indicator to reflect the biological behavior and a predictor of gastric carcinoma.
出处
《临床内科杂志》
CAS
2012年第12期843-845,共3页
Journal of Clinical Internal Medicine
基金
基金项目：中央高校基本科研业务费专项资金资助项目（201130202020005）
