摘要
本文比较研究了不同浸润力的三种人大肠癌细胞的体外浸润力,粘附性,移动性及其对人羊膜基底膜(HABM)浸润的形态特点,实验结果表明人大肠癌细胞浸润力与其粘附性,移动性一致,浸润力与浸润形态相关。高浸润力细胞附着铺展良好,丝状伪足增多,表面镣红阳性外衣增厚,但附着侧外衣减少至消失。提示癌浸润最初步骤为粘附,并启动移动机制,从而表现一系列形态分化。氨基多糖(GAG)可能与浸润过程有关。
The attachment, invasiveness, motility and other biological characteristics of three colorectal carcinoma cell lines (HR-8348, HCe-8693, HR-8348-I1) were comparatively studied, and the relation of them was discussed, The results showed that the invasiveness of the tumor cells were correspondent with their adhesiveness and motility. The highly invasive tumor cells possessed higher adhesiveness, more active motility, thicker ruthenium red-positive coat Those fingings suggest the adhesion, motility and cell surface molecule alterations (eg. glycosaminoglycans, GAGs) may be attributed to the process of tumor invasion.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1991年第4期299-301,共3页
Chinese Journal of Cancer
关键词
大肠肿瘤
浸润力
粘附性
移动性
invasiveness attachment motility Colorectal Carcinoma
