摘要
本文对23例恶性纤维组织细胞瘤((MFH)及19例其他软组织肿瘤的免疫组化研究表明,AACT,AAT阳性率最高,是肿瘤性组织细胞的良好标志物,对MFH有一定诊断价值。Lys不是恶性组织细胞的良好标志物。Des的表达提示部分肿瘤细胞向肌纤维母细胞分化,Vim的表达则提示向纤维母细胞分化。所以,我们的研究结果表明MFH可能来自未分化间叶细胞,并在不同情况下向组织细胞、纤维母细胞和肌纤维母细胞等不同方向分化,而表现出复杂的组织学形态。
23 cases of malignant fibrous histiocytoma (MFH) and 19 cases ofother soft tissue tumors were studied by immunohistochemical technique. The results showed that the highest positivity of AACT, AAT in MFH indicating these may be used as markers of malignant histiocytes and may give diagnostic aid. 'Lys' is a poor marker of malignant histiocytes, while 'Des' expression in some tumor cells was proposed to be a marker for differentiating into myofibroblasts, and 'Vim' expression indicated differentiating into fibroblasts. Our results showed that MFH may be derived from undifferentiated mesen-chymal cells which developed into histiocytes, fibroblasts of myofibroblasts, thus exhibited a mixed histological feature.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1991年第2期107-109,共3页
Chinese Journal of Cancer
关键词
软组织肿瘤
免疫组织化学
MFH
Malignant fibrous histiocytoma, Immunohistochemistry, Tumor marker
