摘要
本实验观察了26例原发大肠癌手术切除标本之癌组织、癌旁粘膜与切除缘牯膜的形态特征、CEA表达强度、细胞DNA含量之差异相互联系。结果见:CEA在癌组织中着色最强、癌旁次之、切除缘最弱。任意二组比较,P<0.005。CEA在中等分化的癌组织、分期较晚的癌组织与非整倍体癌组织中着色较强。细胞核DNA含量均数为:癌细胞组3.358±1.10(Au)、癌旁组2.356±1.07(Au)、切除缘组1.674±0.796(Au),各组比较,差异有显著性。癌旁及切除缘形态正常的粘膜可非整倍体DNA细胞。
The results of morphological changes, expression of CEA and DNAcontent in tumorous tissues, mucosa adjacent to carcinomas and mucosa at resection margin of 26 specimens from patents with large - bowel carcinoma were reported.The intensity of tissue staining for CEA was highest in the tumorous tissues and lowest in the resection margin. Strong staining for CEA was observed also in aneuploid carcinoma, in the later stage of the disease, in the moderately differentiated carcinoma. Significant differences existed in comparison each with others. The mean DNA content was 3.358±1.10(Au) in tumor cells, 2.356± 1.07(Au) in the cells of the mucosa adjacent to the carcinoma and 1.674±0.796 (Au) in the cells of the resection margin. Significant differences existed between these groups when compared each with others. Aneuploid cells were odserved also in the normal mucoca, in the mucosa adjacent to the carcinoma and also in the resection margin.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1991年第1期30-33,共4页
Chinese Journal of Cancer
关键词
大肠肿瘤
癌旁粘膜
上皮细胞
DNA
CEA
large-bowel carcinoma
mucosa adjacent to the carcinoma
resection margin
diagnosis
prognosis
CEA
DNA
