摘要
目的探讨血清基质金属蛋白酶2、9、12（MMP-2、9、12）的含量与吸烟的慢性阻塞性肺疾病急性加重期（AECOPD）的关系,同时观察 MMP-2、9、12的含量与肺气肿程度的相关性.方法选取 AECOPD 患者90例,健康对照者30例（对照组）,采用双抗夹心 ELISA 法测定血清 MMP-2、9、12的含量.结果 AECOPD 患者血清 MMP-2、9、12的水平明显高于对照组,差异有统计学意义（P〈0.05）,AECOPD 患者血清 MMP-2、9、12的含量均与肺功能的严重程度呈正相关.结论 AECOPD 患者血清基质金属蛋白酶的高表达,在 COPD 的发病机制中起了一定的作用,与吸烟人群对 COPD 的易感相关,与 FEV1%占正常预计值,RV/TLC%呈相关性.
Objective To investigate the relationship of serum matrix metalloproteinase 2,9,12 （MMP-2, 9, 12） levels with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods The serum contents of MMP-2, 9, 12 were measured in 90 patients with AECOPD and 30 healthy controls using double-antibody sandwich ELISA method. Results The serum MMP-2, 9, 12 levels were significantly higher in patients with AECOPD than those in healthy controls （P〈0.05）. In patients with AECOPD, serum MMP-2, 9, 12 levels were positively correlated with the severity of lung function. Conclusion Matrix metalloproteinases may be involved in the pathogenesis of COPD and lung function of COPD patients.
出处
《浙江医学》
CAS
2012年第21期1745-1746,1750,共3页
Zhejiang Medical Journal
基金
金华市科技局资助项目（2009-3-028）
