摘要
药源性特异质肝损伤是一种在临床剂量范围内,仅在少数病人身上发生的药物不良反应。由于难以预测,特异质肝损伤带来的危害相对于传统肝损伤来说更为严重,对其产生原因及损伤机制的了解有助于临床的安全用药。综述特异质肝损伤的发生机制及目前采用的研究方法,以为其预防和治疗提供思路。
Idiosyncratic drug induced liver injury(IDILI) is a unique kind of adverse drug reaction,which only happens on a smaller number of patients who take the drug under the clinical dosage.Due to the difficulty of predicting,the damage of IDILI is much more serious than that of the traditional drug liver injury.The occurrence mechanism of IDILI and its research methods were reviewed so as to provide thoughts on the prevention and treatment of idiosyncratic liver injury.
出处
《药学进展》
CAS
2012年第12期546-551,共6页
Progress in Pharmaceutical Sciences
基金
中医药行业科研专项(No.200707008)
关键词
特异质肝损伤
药物不良反应
发生机制
实验模型
idiosyncratic liver injury
adverse drug reaction
occurrence mechanism
experiment model
