摘要
散在重复序列又称转座子元件(transposable element,TE),是细胞中能够通过切割、复制、重新整合等一系列过程改变自身位置的一段DNA序列。TEs可以影响基因组的大小,能够直接或间接促成基因组重排,还可以影响基因表达水平,改写基因调控网络,因此在基因组进化中有重要的意义。本文利用Repeatmasker软件识别小鼠,裸鼹鼠,地松鼠,兔子基因组中的散在重复序列,结合其物种进化关系,比较研究4个物种基因组中TEs类别、拷贝数等情况,为理解重复序列在啮齿类动物中的进化提供了参考信息。
Transposable elements （TEs） are DNA sequences that can move and duplicate, autonomously or with the assis- tance of other elements, within genomes. TEs can affect genome size, and affect genome organization via introducing ma- jor chromosomal rearrangements. They provide regulatory sequences with various effeets on the adjacent genes. Moreover, TEs are intrinsically able to create, modify and re-write gene regulatory networks. Therefore, it is of great importance to investigate TEs content eukaryotic genomes. In this study, by searching against the Repbase library using RepeatMasker, we identified TEs in four rodent species： mouse, nake-mole rat, stried gopher and rabbit. We compared the proportion and classification of TEs in these genomes, and reconstructed their phylogenetic tree. Our work can provide opportunity to get better understanding of TEs evolution in the rodent genomes.
出处
《科技通报》
北大核心
2012年第12期30-31,157,共3页
Bulletin of Science and Technology
